摘要
用不同发育期大鼠的接铅史来探讨铅暴露的敏感期及铅对年轻大鼠空间认知能力的影响。结果发现，生前和生后持续接铅的染毒１组和经母体间接接铅的染毒３组，两者Ｍｏｒｉｓ水迷宫的测试成绩均显著低于对照组，而断乳后接铅的染毒２组，虽然血铅水平显著增高，但脑铅水平和水迷宫测试成绩却与对照组无差别，提示在神经发育早期（胎儿期和婴儿期）对铅更敏感。
We exposed rats to lead at different developmental stages in order to determine the sensitive periods of the exposure and to test the spatial cognitive abilities of rats in the Morris water maze task.The results show that the scores of Morris water maze task are significantly reduced in the prematernally exposed group as compared to the control group,while the postweaningly exposed group did not significantly differ from the control group in spite of its blood lead level significantly higher than the control group.The results reflect the higher vulnerability of the early developing central nervous system than the mature central nervous system to lead-induced deficits.
