摘要
目的 :探讨重症肌无力 (MG)患者的乙酰胆碱受体 (AChR)特异性T细胞免疫应答。方法 :利用酶联免疫斑点技术 (Elispot)检测 32例MG患者胸腺AChR特异反应性白细胞介素 - 4 (IL - 4 )、白细胞介素 - 10 (IL -10 )和干扰素 -γ(IFN -γ)分泌细胞数。结果 :MG患者胸腺AChR特异反应性IL - 4 ,IL - 10和IFN -γ分泌细胞数均增高 ,其中胸腺增生组AChR特异反应性IL - 4 ,IL - 10和IFN -γ分泌细胞数明显高于胸腺瘤组。结论 :MG胸腺Th1和Th2细胞存在免疫功能紊乱 ,胸腺AChR特异反应性IL - 4 ,IL - 10和IFN -γ分泌细胞数可作为判断胸腺Th细胞免疫功能紊乱的指标。
Objective:To study the T-cell mediated immunity against AChR of myasthenia gravis patients.Method:Enzyme-link immunospot(ELISPOT) method is adopted to detect the acetylcholine receptor (AChR)-reactive interleukin-4 (IL-4), interleukin-10 (IL-10), interferon-gamma (IFN-γ) secretive cell numbers in thymus. Results:The AChR-reactive IL-4, IL-10,IFN-γ secretive cell numbers were increased in thymus. They increased more evident in thymus proliferation group than thymoma group.Conclusions:There are immunological function disorder between Th1 and Th2 cells in the thymus of MG,and the AChR-reactive IL-4, IL-10 and IFN-γ secretive cell numbers might be an index to evaluate the degree of immunological function disorder in the thymus of MG.
出处
《中国现代医学杂志》
CAS
CSCD
2002年第19期53-55,共3页
China Journal of Modern Medicine
