摘要
甲状腺癌确诊后,经典的治疗方法是近全切除术后加131I治疗。研究表明,NIS(钠/碘同向转运体)具有聚碘能力,而TPO(甲状腺过氧化物酶)能抑制碘从细胞中流出,NIS和TPC基因联合转染肿瘤细胞介导131治疗有可能成为一种新的治疗方法;维加酸可诱导失分化肿瘤细胞的摄碘能力恢复或提高,也有利于131I治疗。
The classic therapy of metastatic well-differented thyroid cancer is administration of 131 I after subtotal thy-roectomy.The sodium/iodine symporter(NIS)mediates the active transport of iodine into thyroid cells,while the thy-roperoxidase(TPO)suppresses the out-flow of iodine from thyroid cells.As a result,a new potential approach has been develepted with co-transfection of NIS and TPO genes to thyroid cancer cells,which can enhance the results of radioio-dine.Retinoide is also useful to 131 I therapy for it can induce non-differented thyroid cancer cells to well-differnted cells to increase radioiodine uptake.
出处
《国外医学（放射医学核医学分册）》
2002年第4期163-164,168,共3页
Foreign Medical Sciences(Section of Radiation Medicine and Nuclear Medicine)
