摘要
目的评价帕米膦酸二钠 (博宁 )在缓解多发性骨髓瘤患者骨痛中的作用。方法应用博宁联合化疗1 6例与单纯化疗 1 8例进行对照研究。结果博宁联合化疗与单纯化疗均能显著减轻多发性骨髓瘤患者的骨痛程度 (与治疗前比较P <0 .0 1 ) ,博宁联合化疗对骨痛的缓解程度强于单纯化疗 (P <0 .0 5 )。在应用博宁的病例中 ,除 1例出现轻度发热外未见明显毒副作用发生。结论博宁是一种安全有效的双膦酸盐制剂 ,与化疗联合应用可以显著缓解多发性骨髓瘤患者的骨痛。
Objective To evaluate the therapeutic effects of Disodium Pamidronate(Bonin) on bone pain in multiple myeloma. Method 18 patients received only chemotherapy and 16 patients with addition of Bonin were compared. Result The bone pain was significantly relieved both in chemotherapy alone group and in the combination group of Bonin with chemotherapy after treatment(P<0.01,as compared with before therapy). However, the effects of combination group were more dramatical than that of the other group(P<0.05).No obvious side effects were observed except mild fever in one patient in the combination group. Conclusion Bonin, as a safe and effective Bisphosphonates preparation, could relieve bone pain in multiple myeloma more effectively when combined with chemotherapy.
出处
《航天医学与医学工程》
CAS
CSCD
北大核心
2002年第5期377-378,共2页
Space Medicine & Medical Engineering
