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放射免疫法研究乳糖基重组人生长激素和重组人生长激素的药代动力学 被引量：1

Pharmacokinetic Analysis for Lactosaminated Recombination Human Growth Hormone and Recombination Human Growth Hormone by Radioimmunoassay
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摘要 目的 :比较研究乳糖基重组人生长激素 (L -rhGH )和重组人生长激素 (rhGH )在小鼠血和肝中的药代动力学。方法 :用注射免疫法测定L -rhGH和rhGH在小鼠血、肝脏中的药物浓度。结果 :静脉注射后 ,两者的药代动力学过程存在显著性差异 ,L -rhGH在肝中的分布量较rhGH增加 ,且T1/2 仅为rhGH的17 9 % ;L -rhGH在血中亦表现为短维持时间、低分布量。结论 :L OBJECTIVE:To study the pharmacokinetics of L-rhGH and rhGH in mice.METHODS:The concertrations of L-rhGH and rhGH in plasma and liver were measured by radioimmunoassay.RESULTS:After intravenous injection,there were significant differences between L-rhGH and rhGH in pharmacokinetic parameters.The Cmax of L-rhGH in the liver was higher than that of rhGH but the T1/2 of L-rhGH was only 17.9% of T1/2 of rhGH;the Cmax of L-rhGH in plasma was lower than that of rhGH and the T1/2 was shorter.CONCLUSION:L-rhGH reveals the pharmacokinetic characteristics which fits in with the physiology of human body.
作者 陈泽莲 李铜玲 庞其捷 何菊英 彭永富 李云春 管昌田
机构地区 四川大学华西医院药剂科 四川大学药学院 第三军医大学西南医院药剂科 四川大学华西医院核医学科
出处 《中国药房》 CAS CSCD 2002年第10期583-584,共2页 China Pharmacy
基金 国家自然科学基金资助项目 (39670861)
关键词 乳糖基重组人生长激素 重组人生长激素 药代动力学 放射免疫法 lactosaminated recombination human growth hormone recombination human growth hormone pharmacokinetics radioimmunoassay
分类号 R969.1 [医药卫生—药理学] R977.1 [医药卫生—药品]
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参考文献4

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中国药房
2002年 第10期

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