摘要
目的探讨维生素D受体(VDR)基因多态性与银屑病的关系。方法采用聚合酶链反应和限制性片段长度多态性(PCR-RFLP),对112例无血缘关系的银屑病患者和108例无血缘关系的健康人员的VDR基因型进行分析。结果AA、Bb基因型在健康人中出现的频率仅7.4%及14.8%,而在银屑病人中出现的频率为19.6%及32.1%。进一步分析VDR基因型与银屑病患者性别、发病年龄、家族史等的关系,未发现显著相关。在统计等位基因A、a和B、b时,发现它们在两组人群中出现的频率差异均无显著性。结论维生素D受体(VDR)基因型分布在银屑病患者与健康人中是显著不同的,纯合子AA基因型或杂合子Bb基因型的出现可能增加患银屑病的易患性。
Objective To study the correlation between vitamin D receptor(VDR)polymorphism and psoriasis in the Chinese patients.Methods VDR genotypes were determined by PCR-RFLP in 112unrelated psoriatic patients as well as 108unr elated healthy controls.Results AA and Bb genotypes were found to be ex-pressed more frequently in psoriatic patients(19.6%and 32.1%)than those in normal controls(7.4%and14.8%),respectively.However,no signifi cant correlation was identified between VDR polymorphismand sex,age at onset,family history of psoriasis in psoriatic patients.In addition,there was no significant difference in the fre-quency of A,a alleles and B,b alleles between normal controls and psoriatic patients.Conclusions There is a significant difference in VDR genotypes between psoriatic patients and normal controls.The presence of hom ozygote AA or heterozygote Bb might contribute to the susceptibility of psoriasis.
出处
《中华皮肤科杂志》
CAS
CSCD
北大核心
2002年第5期386-388,共3页
Chinese Journal of Dermatology
基金
中华医学会皮肤科学会科研基金资助课题(2000年度杨森基金)
