摘要
用四醋酸铅将七元 (6 O 二甲基叔丁基硅基 ) β 环糊精选择氧化、并用三氟化硼乙醚脱硅基保护基后 ,再经分离、纯化 ,可获得具有“楔筒状”空腔的单 2 ,3 二醛基 β 环糊精 .单 2 ,3 二醛基 β 环糊精较 β 环糊精有更好的水溶性 .用单 2 ,3 二醛基 β 环糊精作TLC流动相手性添加剂时 ,可将肾上腺素对映体在硅胶薄层板上有效拆分 .
Cyclodextrin with the 6 hydroxyls protected by dimethyl tert butylsilyl was selectively oxidized by lead tetraacetate. After the silyl groups were removed off by boron fluoride etherate,mono 2,3 dialdehydo β cyclodextrin as a cuniform molecule could be constructed. Mono 2,3 dialdehydo β cyclodextrin is more soluble in water than β cyclodextrin. Mono 2,3 dialdehydo β cyclodextrin could be used as the mobile phase additives for effective resolution of DL adrenaline on silica gel plates.
出处
《化学学报》
SCIE
CAS
CSCD
北大核心
2002年第8期1536-1538,共3页
Acta Chimica Sinica
基金
国家自然科学基金 (No .2 990 2 0 0 4)
