摘要
新催化合成方法具有环境友好性和原子经济性,已成为未来化学工业发展的关键技术。含肽化合物是有用的农用和医用化学品,其工业生产方法大都采用光气作羰基化试剂,光气的高毒性和苛刻的操作条件有诸多的不便。以非金属硒作催化剂、CO为羰基化试剂,可一步催化合成非对称脲类化合物或其衍生物。通过硒催化羰基化,还可以合成咪唑啉酮、(?)唑烷酮、环脲等;采用CO/H2O/Se催化体系,可以高选择性制备(取代)苯胺。本文介绍了二级胺、一级胺和4-氨基吡啶为共试剂的硝基化合物的羰基化反应情况。
New catalytic process featuring environmental kindness and atom economical selectivity, has been become a key technology for further development of chemical industry in the future. Compounds containing peptide are known to be useful agrochemicals and pharmaceuticals, the phosgene is usually used as carbonylating agent in their industrial synthesis, but it involves inconvenient critical processing conditions due to its high toxicity. Using non metallic selenium as catalyst, CO as carbonylation agent, unsymmetric ureas and their derivatives can be synthesized catalytically in one step. Imidazolin-one, oxazolidone and cyclic ureas can also synthesize by selenium-catalytic carbonylation. Aniline or its substitutes can be obtained also with high selectivity by using of CO/H2O/Se catalytic system. In this paper carbonylation of nitro compounds with co-reagent based on secondary amine, primary amine and 4-aminopyridine is detailed.
出处
《精细与专用化学品》
CAS
2002年第18期6-8,共3页
Fine and Specialty Chemicals
