摘要
目的 探讨老年原发性高血压脉压与脑血流动力学变化的关系。为高血压防治、减少脑卒中的发生提供依据。 方法 将 77例老年原发性高血压患者按脉压≤ 60mmHg、61～ 90mmHg、>90mmHg分为 3组 ,用经颅多普勒 (TCD)监测分析 ,观察大脑中动脉 (MCA)的收缩期血流速度 (Vs)、平均血流速度 (Vm)、舒张期血流速度(Vd)、搏动指数 (PI)、阻力指数 (RI)、收缩期与舒张期血流速度比值 (SD)的变化特征 ,并与收缩压 (SBP)、舒张压(DBP)、平均动脉压 (MAP)、脉压 (PP)进行了相关分析。 结果 随着年龄增大 ,PP逐渐增大 (P <0 0 1) ,Vd降低(P <0 0 5 ) ,PI、RI增高 (P <0 0 1) ,SD比值增大 (P <0 0 1) ;SBP、PP与SD、PI、RI呈明显正相关 (P <0 0 1) ,DBP与SD、PI、RI呈明显负相关 (P <0 0 5 ) ,MAP均与脑血流各指标无明显相关 (P >0 0 5 )。 结论 老年原发性高血压患者随着PP增大 ,脑血管损害加重 ,脑血流动力学的变化与SBP、PP密切相关。
Objective To explore the relationship between pulse pressure and cerebral hemodynamics in senile patients with essential hypertension and to provide evidence to prevent essential hypertension and stroke in the aged. Methods Seventy seven senile patients with essential hypertension were divided into three groups according to mean pulse pressure(PP)≤60 mmHg,61～90 mmHg and >90 mmHg.We analyzed the TCD parameters such as systolic velocity(Vs),mean velocity(Vm),diastolic velocity(Vd),pulsatility index(PI),resistance index(RI) and systolic diastolic ratio (SD)of middle cerebral arteries.Systolic blood pressure(SBP),diastolic blood pressure(DBP),mean artery blood pressure(MAP) and pulse pressure(PP)were measured and analyzed. Results The pulse pressure(PP),pulsatility index(PI),resistance index(RI),systolic diastolic ratio(SD)increased with increasing PP ( P <0 01),but diastolic velocity(Vd)decreased( P <0 05).Compared with the TCD parameters,SBP,PP were significantly positively correlated with Sd,PI and RI( P <0 01).There was negative correlation between DBP and SD,PI and RI( P <0 05).No significant correlation between MAP and TCD parameters was observed( P >0 05). Conclusions Cerebra arteries were damaged with increasing pulse pressure(PP)in senile patients with essential hypertenion.The changes of cerebral hemodynamics were significantly positively correlated with sytolic blood pressure(SBP)and pulse pressure(PP).
出处
《实用老年医学》
CAS
2002年第5期244-246,共3页
Practical Geriatrics
关键词
高血压
脉压
脑血流动力学
Senile essential hypertension
Pulse pressure
Cerebral hemodynamics
