摘要
目的 探讨内皮素 1 (ET 1 )、血栓素B2 (TXB2 )、6 酮 前列腺素F1α(6 K PGF1α)、血气(PaO2 、PaCO2 、pH等 )、平均动脉压 (MAP)、心率、呼吸、放射性核素肺灌注显像和心肺组织病理等指标在细粒棘球蚴内容物致家兔急性肺栓塞 (acutepulmonaryembolism ,APE)发病中的变化、作用、意义及相互关系。方法 每只家兔都用相同方法将导管置入股动脉及股静脉 ,按 2ml/kg分别自股静脉导管缓慢注射生理盐水、澄清囊液、含囊砂的悬浊液。动态监测各项指标的变化。结果 A组动物 :各项指标在注射盐水前、后各时刻无明显变化 (P >0 0 5)。B组和C组 :ET 1在分别注射囊液与囊砂悬浊液前、后各时刻无明显变化 (P >0 0 5) ,B组栓塞后TXB2 、6 K PGF1α升高 (P <0 0 5) ,C组栓塞后TXB2 、6 K PGF1α均升高明显 (P <0 0 1 ) ,B、C组动物MAP、血气、放射性核素肺灌注显像、心肺组织病理也均有相应的变化。结论 ET 1、TXB2 、6 K PGF1α在细粒棘球蚴内容物致家兔APE发病机制中起重要作用 ,尤其是在C组更为突出。悬浊囊液入血循环后 ,所造成的影响较澄清囊液入血循环要严重 ,提示囊液中有形成分在肺栓塞中起着重要的作用 。
Objective To investigate the role of blood vessel active substances, such as endothelin 1(ET 1),thromboxane B 2(TXB 2),and 6 keto prostaglandin F 1α (6 K PGF 1α ) in a rabbit model of acute pulmonary embolism induced by echinococus granulous cyst Methods Catheters were placed into the femoral artery and the femoral vein Saline, fresh clear cyst fluid or sand containing cyst fluid in a volume of 2 ml/kg were infused through the femoral vein catheter Changes of ET 1, TXB 2 and 6 K PGF 1α were measured; PaO 2,PaCO 2,pH, MAP, heart rate, and respiration rate were recorded; and radionuclide lung perfusion scan and the change of heart and lung pathology were studied Results The changes of the studied parameters were not remarkable in the saline treated animals ( P >0 05) TXB 2 and 6 K PGF 1α were elevated in the cyst fluid treated animals( P <0 05) PaO 2, PaCO 2, and MAP declined in the clear cyst fluid group ( P <0 05), but their changes were more significant in animals treated with sand containing cyst fluid Radionuclide lung perfusion scan showed radioactivity defect or attenuation Histological examination of the lungs revealed diffuse alveolar damage Conclusions Sand containing cyst fluid caused a more severe disease in this rabbit model of acute pulmonary embolism, suggesting that it played an important role in the induction of lung damage
出处
《中华结核和呼吸杂志》
CAS
CSCD
北大核心
2002年第10期598-602,I002,共6页
Chinese Journal of Tuberculosis and Respiratory Diseases
基金
国家自然科学基金资助项目 ( 3986 0 0 78)
