摘要
目的 探讨牛磺酸 (Tau)对异丙肾上腺素 (ISP)引起的心肌损伤中钙代谢的影响。 方法 取 3月～5月龄健康Wistar大鼠 5 6只 ,制作离体心脏标本 ,按随机原则分为对照组、Tau组、ISP组及不同浓度Tau +ISP组。在Langendorff装置进行心肌4 5Ca摄取与释放试验灌流。收集标本进行4 5Ca放射性测定。 结果 ISP促进心肌细胞4 5Ca摄取 ,抑制心肌细胞4 5Ca释放。Tau则可抑制ISP导致的心肌细胞4 5Ca摄取 ,同时也能拮抗ISP抑制心肌细胞4 5Ca释放。 结论 牛磺酸具有抑制心肌4 5Ca摄取和促进4 5Ca释放的作用 ,从而抑制ISP导致的心肌细胞钙超载。
Objective To seek for the effect of taurine in calcium metabolism of cardiac muscle which was harmed by isoproterenol(ISP). Methods The isolated heart samples were made from 56 healthy wistar rats of 3～5 month aged,and divided randomly into control group,tanrine group.ISP group and different concentration taurine+ISP groups,then all they were put into langendorff equipment. All the tested samples were collected and assessed by radioactive assay. Results ISP could advance 45 Ca uptake and inhibit 45 Ca release in the myocardial cell and taurine had the antagonistic effect. Conclusion Taurine has the function which inhibition 45 Ca uptake and increases 45 Ca release,so it can correct the adverse effect of ISP and protect myocardial cell.
出处
《实用心脑肺血管病杂志》
2002年第5期262-264,共3页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
