摘要
目的 :探索酪氨酸与依那普利、硝苯吡啶在高原低氧条件下对移居者负荷运动后血氧饱和度与肺通气功能的影响 ,为药物提高和改善低氧环境下人脑 -体功效能力提供科学依据 ;方法 :选择某部驻守海拔 3 70 0m 6个月的健康男性青年 3 0名 ,分 3组 ,甲组口服炒面胶囊 ( 1 0人 ,对照组 ) ,乙组口服酪氨酸 ( 1 0人 ) ,丙组口服依那普利和硝苯吡啶( 1 0人 ) ,连续服药 1 5天 ,于服药前、服药 1 5天、停药 1 0天 3个阶段应用EGM型自行车功量仪进行负荷运动 (运动负荷指标 :W 2 2 5P1 75次 /分～ 1 80次 /分 ) ,运动后 5分钟进行SaO2 (血氧饱和度 )和肺功能检测 ;结果 :服药前运动前SaO2 显著高于服药前运动后、服药 1 5天运动后、停药 1 0天运动后 (P <0 .0 1 ) ,服药 1 5天运动后和停药 1 0天运动后乙、丙组SaO2 显著高于甲组及服药前运动后甲、乙、丙组SaO2 ,服药前运动前、后 ,服药 1 5天运动后及停药 1 0天运动后肺通气功能无显著性改变 (P >0 .0 5) ;结论 :酪氨酸与依那普利、硝苯吡啶能有效的提高人体在低氧条件下负荷运动后的SaO2 ,可能是通过增强氧的弥散和运输、促进氧利用的药物生理效应而发生作用的 ,停药 1 0天后仍能保持一定的SaO2 含量。
To study the effect of tyrosine and enalapril and nifedipine on lung function and blood oxygen saturation (SaO 2) following loaded exercise at high altitude.Method:30 subjects were randomly divided into tyrosine group,enalaril+nifedipine group and placebo group,who have stayed 3 700m altitudes for 6 months,and constantly pedalled the EGM effciency bicycle as loaded exercise(index:efficiency 225W,heart rate 170～180 bpm),to determine their SaO 2 and lung function before and after taking medicine for 15 days,and the 10th day while they had stopped taking medicine.Results:The SaO 2 which have gained at rest were higher than that after exercise,for 15 days and the 10th day(P<0.01).Taking medicine for 15 days and the 10th day,the SaO 2 in medicine′s group were increased,but the lung function has no discrepancy(P>0.05).Conclusion:Both tyrosine and enalapril and nifedipine could improve the SaO 2 following loaded exercise at high altitude,and the medicine′s efficancy could retains up to 10 days.
出处
《高原医学杂志》
CAS
2002年第3期20-22,共3页
Journal of High Altitude Medicine
