摘要
目的 :评价单层或多层羊膜移植手术治疗严重眼表疾病的临床效果。方法 :对 48例 5 1只眼各类眼表疾病患者采用低温保存 (- 80℃ )人羊膜行单层、双层或多层羊膜移植手术以重建正常眼表结构。结果 :术后随访 3～ 2 0个月 ,44例 47只眼成功再造眼表结构 ,2例 2只眼因角膜缘干细胞严重缺乏 ,术后羊膜植片发生溶解 ,1例 1只眼睑球粘连复发 ,1例 1只眼复发性翼状胬肉再次复发 ,一次手术治愈率为 92 2 %。 2例再次手术行羊膜移植联合健眼角膜缘干细胞组织移植 ,重建眼表获得成功。结论 :羊膜移植手术可有效治疗眼表疾病 ,重建正常眼表结构。对合并角膜缘干细胞严重缺乏的病例 。
Objective:To evaluate the efficacy of treatment for serious ocular surface diseases with transplantation of amniotic membrane. Methods:Monolayer,double layer or multiple layer cryopreserved (-80℃) human amniotic membrane were transplantated for ocular surface reconstruction in 48 patients (51 eyes) with various ocular surface diseases.Results:Patients were followed up for 3～20 months,and in 44 patients (47 eyes)the results were successful,but in 2 patients (2 eyes) the amniotic membrane grafts were dissolved because of severe deficiency of limbal stem cell and the conjunctival symblepharon in 1 patient (1 eye) and the recurrent pterygium in other patient (1 eye) recurred.The curative rate of primary amniotic membrane transplantation was 92.2%.To the 2 eyes with deficiency of limbal stem cells,amniotic membrane combined with limbal stem cells were transplantated again,and the treatment was successful.Conclusions:Amniotic membrane transplantation can be used to reconstruct ocular surface effectually.Transplantation of limbal stem cell should be performed simultaneously in cases combined with deficiency of limbal stem cell.
出处
《眼科》
CAS
2002年第5期278-280,共3页
Ophthalmology in China
