摘要
目的总结抗SSA阳性类风湿关节炎病例特点。方法总结28例抗SSA阳性类风湿关节炎患者的临床资料,包括关节受累情况、受累关节数、抗CCP、RF、抗核抗体谱、CRP、ESR。结果抗SSA阳性的类风湿关节炎患者多为女性,抗CCP抗体、RF高滴度阳性(>正常值3倍以上)的患者有20例(71.4%),治疗后,其水平仍维持在高滴度。有4例同时有抗SSB阳性,其中2例(7.1%)就诊时合并干燥综合征(SS),1例在诊治10个月后发展成系统性红斑狼疮,另1例随访至投稿,该患者于诊断为RA 51个月后继发了SS。在随访30个月中,该组患者的CRP、ESR水平均高于正常值,说明该组患者病情控制欠佳。结论抗SSA阳性可能是提示难治性及预后较差的类风湿关节炎的一个指标。
Objective To conclude positive anti-SSA rheumatoid arthritis (RA). Methods To summarize the clinical data of 28 cases of SSA positive patients with rheumatoid arthritis including Joint Involvement, anti-CCP, RF, ANA, CRP and ESR. Results Incidence of RA with positive anti-SSA in women is higher than that in man. Anti-CCP and RF were positive with high titer in 20 patients, eventhough after therapy. There is 4 of these patients were dectectived positive anti-SSB, simultaneously. 2 patients of the 4 were diagnosed as RA and SS; 1 patient developed to SLE, and 1 patient was diagnosed as secondary SS after 51 months. All patients were in high level of CRP and ESR for follow-up visit in 30 months. It suggested that disease was uncontrolled. Conclusion Maybe, positive Anti-SSA can be an index of RA with refractory and poor prognosis.
出处
《当代医学》
2016年第23期10-11,共2页
Contemporary Medicine
