奈达铂联合氟尿嘧啶与顺铂联合氟尿嘧啶治疗老年晚期食管癌效果的对比观察被引量：4

Comparison of curative effect of nedaplatin combined with 5-fluorouracil and cisplatin combined with 5-fluorouracil in the treatment of elderly patients with advanced esophageal cancer

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摘要目的:对比奈达铂(NDP)联合氟尿嘧啶(5-FU)与顺铂(DDP)联合氟尿嘧啶治疗老年晚期食管癌的效果和不良反应。方法:收治老年晚期食管癌患者46例,随机分为NDP+5-FU治疗组(A组,24例)和DDP+5-FU对照组(B组,22例),比较两组患者的疗效和不良反应。结果:A组总有效率27.53%,B组总有效率22.73%(P<0.05)。A组主要不良反应为骨髓抑制,B组主要不良反应为消化道反应。结论:奈达铂治疗老年晚期食管癌患者的效果显著,不良反应小。 Objective:To explore the curative effect and adverse reactions of nedaplatin combined with 5-fluorouracil andcisplatin combined with 5-fluorouracil in the treatment of elderly patients with advanced esophageal cancer.Methods:46 elderlypatients with advanced esophageal cancer were selected,they were randomly divided into NDP+5-FU treatment group(A group,24cases) and DDP+5-FU control group(B group,22 cases),we compared the efficacy and adverse reactions of the two groups.Results:The total effective rate in the A group was 27.53%,and the total effective rate in the B group was 22.73%(P<0.05).In the A group,the main adverse reactions were bone marrow suppression,in the B group,the main adverse reactions were gastrointestinalreactions.Conclusion:Effect of nedaplatin in the treatment of elderly patients with advanced esophageal carcinoma was significant,adverse reaction was small.

作者邹乐乐关红梅杨莹陈宛丽 Zou Lele;Guan Hongmei;Yang Ying;Chen Wanli(Department of Hematology Oncology,the Second People's Hospital of Nanyang City,Henan Province 473000)

机构地区河南省南阳市第二人民医院血液肿瘤科

出处《中国社区医师》 2015年第34期21-22,共2页 Chinese Community Doctors

关键词奈达铂食管癌化疗老年 Nedaplatin Esophageal cancer Chemotherapy The elderly

分类号 R735.1 [医药卫生—肿瘤]

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1王建坡,周福有,赵学科,张朋,张伟,彭秀青,焦新英,王青玉,韩敏,申芳芳,王立东.食管癌高/低发区1975～2011年42082例食管鳞状细胞癌患者年龄、性别和家族史分析[J].河南大学学报（医学版）,2012,31(3):171-175. 被引量：14
2程欣,陈思禹,刘福国,郭惠琴.食管癌化疗进展[J].癌症进展,2013,11(5):425-430. 被引量：21
3徐瑞华,史艳侠,管忠震,姜文奇,黄河,马智勇,王建华,胡晓桦,谢伟敏,李星庚,刘亚利,潘良熹,戴爱娣,庄武,张春.国产奈达铂治疗食管癌的Ⅱ期临床试验报告[J].癌症,2006,25(12):1565-1568. 被引量：44

二级参考文献26

1Cunningham D,Allum WH,Stenning SP,菅鑫妍.手术期间化学疗法与单独手术治疗可切除的胃食管癌疗效比较[J].中国处方药,2006,5(8):59-60. 被引量：434
2王立东,樊慧,焦新英,宋昕,杜娴娟,李吉林,张广平,常志伟,范宗民.河南食管癌高发区95对单卵双胞胎疾病谱和2323例食管癌患者家族史调查[J].中华肿瘤防治杂志,2006,13(20):1521-1524. 被引量：31
3Hirata S,Yatsuyanagi E,Yamazaki H,et al.Neoadjuvant chemotherapy for esophageal cancer by administration of nedaplatin alone[J].Gan To Kagaku Ryoho,2000,27 (2):221-226.
4Yamanaka H,Motohiro T,Michiura T,et al.Nedaplatin and 5-FU combined with radiation in the treatment for esophageal cancer[J].Jpn J Thorac Cardiovasc Surg,1998,46 (10):943-948.
5Yoshioka T,Gamoh M,Shineha R,et al.A new combination chemotherapy with cis-diammine-glycolatoplatinum(Nedaplatin)and 5-fluorouracil for advanced esophageal cancers[J].Intern Med,1999,38 (11):844-848.
6Inuyama Y,Miyake H,Horiuchi M,et al.A late phase Ⅱ clinical study of cis-diammine glycolato platinum,254-S,for head and neck cancers[J].Gan To Kagaku Ryoho,1992,19(6):871-877.
7Ota K.Nedaplatin[J].Gan To Kagaku Ryoho,1996,23(3):379-387.
8Taguchi T,Wakui A,Nabeya K,et al.A phase Ⅱ clinical study of cis-diammine glycolato platinun,254-S,for gastrointestinal cancers.254-S Gastrointestinal Cancer Study Group[J].Gan To Kagaku Ryoho,1992,19(4):483-488.
9Ilson D H.New developments in the treatment of esophageal cancer[J].Clin Adv Hematol Oncol,2004,2(2):97-104.
10Jema[ A, Bray F, Center M M, eta[. Global cancer sta- tistics [J]. CA Cancer J Clin, 2011, 61(2) :69.