摘要
目的:探讨血清肿瘤标志物检测对诊断肺癌患者的临床价值。方法:收治疑似肺癌患者64例作为临床研究对象,分别检测血清细胞角蛋白19片段(CYFRA21-1)、癌胚抗原(CEA)、神经元特异性烯醇化酶(NSE)、胃泌素释放肽前体(Pro GRP)的水平,评价四项肿瘤标志物单独检测及联合检查的敏感度与特异性。结果:肺癌患者的各项指标水平均显著高于非肺癌患者,差异具有统计学意义(P<0.05)。各标志物单独检测的阳性率、敏感度、特异度明显低于联合检测,差异具有统计学意义(P<0.05)。结论:联合检测CYFRA21-1、CEA、NSE、Pro GRP可有效辅助诊断肺癌,为肺癌患者的预后提供客观的参考依据。
Objective:To investigate the clinical value of serum tumor markers detection in the diagnosis of patients with lung cancer.Methods:64 cases of patients with suspected lung cancer were as the clinical study object and whose serum levels of cytokeratin 19 fragment (CYFRA21-1),carcinoembryonic antigen (CEA),neuron specific enolase (NSE),pro-gastrin-releasing peptide were detected,and the sensitivity and specificity of individual four tumor markers detection and joint detection were evaluated.Results:The every indexes of patients with lung cancer were significantly higher than that of patients without lung cancer,and the differences were statistically significant(P<0.05).The positive rate,sensitivity and specificity of each marker were significantly lower than that of the joint detection,and the differences were statistically significant(P<0.05).Conclusion:Joint detection of CYFRA21-1,CEA,NSE,ProGRP could assist the diagnosis of lung cancer effectively and provide objective reference for the prognosis of patients with lung cancer.
作者
吴旭波
Wu Xubo(Clinical Laboratory,the People's Hospital of Wenjiang District of Chengdu City 611130)
出处
《中国社区医师》
2016年第10期115-116,共2页
Chinese Community Doctors
关键词
肺癌
血清肿瘤标志物
联合检测
Lung cancer
Serum tumor markers
Joint detection
