摘要
目的：验证鲜鬼针草的降压疗效。方法：使用生鲜鬼针草提取液，对原发性高血压大鼠采用无创血压测试仪，测定给药前和给药后30～360min多个时间段尾动脉SBP值。结果：鲜药给药相当于临床剂量组12倍后有明显降压作用，维持降压时间2h左右；全心指数结果表明，对心肌有保护作用，能改善高血压大鼠心肌肥厚状况；进行药物的急性毒性实验，说明药物应用安全。
Objective: To test the antihypertensive effect of fresh bidens bipinnata L.. Method: Check primary hypertension rat’s tail artery systolic pressure before and after administration of 30 min to 360 min for more than one time with noninvasive blood pressure testing apparatus. Each one of the essential hypertensive rats are fed with bidens bipinnata L. extract. Result:The antihypertensive effect was obvious when dosage of fresh herbs was equivalent to 12 times the clinical dosage group, and the effect continued for about 2 hours.Fresh bidens bipinnata L. could protect myocardium and improve the cardiac hypertrophy in hypertensive rats. The acute toxicity test showed that the drug was safe.
出处
《中医临床研究》
2016年第24期16-19,共4页
Clinical Journal Of Chinese Medicine
基金
安徽省卫生计划生育委员会"十二五"中医心血管重点学科项目
关键词
鲜鬼针草
降压作用
实验研究
Fresh bidens bipinnata L.
Antihypertensive effect
Experimental Study
