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纳米微针导入0.5%氨甲环酸溶液对中国女性面部皮肤暗沉的疗效研究 被引量:9

Effect of 0.5% tranexamic acid solution into skin with microneedles for facial skin dull of Chinese women
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摘要 目的:研究经纳米微针导入0.5%氨甲环酸溶液对中国女性面部皮肤暗沉的疗效及安全性。方法:募集60名无基础病的健康临床受试者,随机分为两组,每组30名。生理盐水组:受试者全面部使用纳米微针导入生理盐水;0.5%氨甲环酸溶液组:受试者全面部使用纳米微针导入0.5%氨甲环酸溶液。两组受试者均每周接受1次治疗,共治疗2个月,每周两组受试者接受治疗前及治疗后72h都检测经皮水分丢失(trans-epidermal water loss,TEWL)、角质层含水量、红斑量、黑素及皮肤弹性,拍摄每组受试者治疗前后面部照片。通过皮肤状态问卷调查受试者满意度及不良反应,治疗结束后1个月、2个月复测TEWL、角质层含水量、红斑量、黑素及皮肤弹性。结果:生理盐水组治疗后72h经皮水分丢失、角质层含水量、红斑量、皮肤弹性与0.5%氨甲环酸溶液组无显著性差异;生理盐水组治疗后黑素数值显著高于0.5%氨甲环酸溶液组;生理盐水组受试者面部照片治疗前后无显著性差异,0.5%氨甲环酸溶液组治疗后面部照片明显比治疗前肤色白皙;生理盐水组受试者及医生满意度显著低于0.5%氨甲环酸溶液组;生理盐水组及0.5%氨甲环酸溶液组皆无不良反应;0.5%氨甲环酸溶液组治疗后1个月的黑素值与初次治疗前的黑素值有显著性差异(P<0.05),治疗后2个月的黑素值与初次治疗前测得的黑素值无统计学差异。结论:纳米微针导入0.5%氨甲环酸溶液可明显改善中国女性面部皮肤暗沉。 Objective To observe the clinical effect of delivering 0.5% tranexamic acid solution into skin with microneedlesfor facial skin dull of Chinese women. Methods A total of 60 healthy subjects were enrolled for this study and wererespectively divided into 2 groups. 60 cases volunteers were treated by deliverying solution into skin through microporeswhich the microneedles made. In the first group, volunteers were treated by deliverying physiological saline solution into skin. In the second group, volunteers were treated by deliverying 0.5% tranexamic acid solution into skin . One session every 7days, all 60 volunteers were treated 8 times. We asses its effect by questionaires for subjective evaluation and side effect, andobjective evaluation with digital skin analyzers to record raw pictures and data before and after treatment. Retesting TEWL,skin hydration, erythema dose, melanin value and skin elasticity at the ending of 1, 2 months after all treatment. ResultsThere was no significant difference in TEWL, skin hydration , erythema dose, melanin and skin elasticity between the salinegroup and the 0.5% tranexamic acid solution group. Melanin of 0.5% tranexamic acid solution group was relatively lowerthan the saline group. There was no significant difference in facial photo before and after treatment in the saline group, skincolour was obviously pale compared to that before treatment in the 0.5% tranexamic acid solution group.The subjects anddoctors’ satisfaction of the saline group was relatively lower than that of the 0.5% tranexamic acid solution group . There wasno adverse reaction report both in the saline group and the 0.5% tranexamic acid solution group. In the 0.5% tranexamic acidsolution group , there were significant differences in melanin value before and 1 month after the treatment , while there were no statistical differences before and 2 month after the treatment . Conclusion Delivering 0.5% tranexamic acid solution into skinwith microneedles can significantly improve the facial skin dull of Chinese women .
作者 吴亭妍 周炳荣 易飞 陶艳玲 苗颖颖 倪娜 马仁燕 许阳 徐百 骆丹 WU Ting-yan;ZHOU Bing-rong;YI Fei;TAO Yan-ling;MIAO Ying-ying;NI Na;MA Ren-yan;XU Yang;XU Bai;LUO Dan(Department of Dermatology, the First Affiliated Hospital with Nanjing Medical University, Nanjing 210029,Jiangsu,China;Suzhou Nanomed Skincare Inc , Suzhou 215000, Jiangsu, China)
出处 《中国美容医学》 CAS 2016年第9期87-90,共4页 Chinese Journal of Aesthetic Medicine
关键词 纳米微针 氨甲环酸 生理盐水 黑素 皮肤暗沉 nanometer microneedle tranexamic acid physiological saline solution melanin value facial skin dull
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参考文献10

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