摘要
近年来,基于两亲性聚合物的胶束在生物学领域中的应用备受人们的关注,其中疏水改性多糖(两亲性多糖)自聚集胶束是其中的典型例子。两亲性多糖在水相体系中可自发形成具有壳核结构的胶束,可用于疏水性物质增溶、靶向运输、控制释放及提高其生物活性等。本文对两亲性多糖的制备方法、自聚集胶束的特性(临界胶束浓度、大小、形状、ζ-电位、多分散指数、荷载能力等)及其影响因素(基质浓度、疏水化程度、分子质量、p H值、温度、添加物等)进行全面综述,同时对该领域今后的发展方向进行了展望。
In recent years, the application of amphiphilic polymer micelles especially hydrophobically-modified polysaccharides (amphiphilic polysaccharides) self-aggregated micelles in the field of biology has attracted increa singscientific interests. Amphiphilic polysaccharides can form a core-shell micellar structure in aqueous system, which can beused for solubilizing hydrophobic substances, targeted drug delivery, controlling release, improving biological activitiesand so on. This paper summarizes recent progress in the synthesis of amphiphilic polysaccharides, and understanding theproperties of self-aggregated micelles such as critical micelle concentration (CMC), size, shape, zeta potential, dispersion index and load capacity as well as the factors influencing them including substrate concentration, degree of hydrophobicity,molecular weight, pH, temperature, and other additives. Finally, we conclude with future research directions in this area.
作者
肖丽
叶发银
赵国华
XIAO Li;YE Fayin;ZHAO Guohua(College of Food Science, Southwest University, Chongqing 400715, China;Chongqing Special Food Programme and Technology Research Center, Chongqing 400715, China)
出处
《食品科学》
EI
CAS
CSCD
北大核心
2017年第1期263-268,共6页
Food Science
基金
国家自然科学基金面上项目(31371737)
中央高校基本科研业务费专项(XDJK2014C069)
重庆市特色食品工程技术研究中心能力提升项目(cstc2014pt-gc8001)
关键词
两亲性多糖
胶束
制备
自聚集
特性
因素
amphiphilic polysaccharide
micelles
preparation
self-aggregation
properties
factors
