摘要
目的传统的甲状腺摄取系统(Thyroid Uptake System,TUS)常常不能准确测定甲状腺摄锝率,本文探讨注射高锝酸盐(^(99m)Tc O4)后SPECT/CT断层显像在甲状腺摄锝功能检测中的效用。方法对60例甲状腺检查者进行回顾性分析,包括20例毒性弥漫性甲状腺肿(Graves病)、15例甲状腺炎和25例甲状腺机能正常。所有患者均注射^(99m)Tc O4行单光子发射计算机断层成像术(Single-Photon Emission Computed Tomography,SPECT)/CT(185 MBq=5 m Ci)断层显像,计算甲状腺摄锝率和标准摄取值(Standardized Uptake Value,SUV),其中Graves病和甲状腺炎患者同时接受传统的甲状腺摄取系统测定。结果 SPECT/CT定量评估参数(甲状腺摄锝率、标准摄取平均值和标准摄取最大值)在Graves病中最大,其次是甲状腺炎,最小是甲状腺机能正常(P<0.001);由于传统的TUS测试前位颈部的放射性计数,较SPECT/CT而言显著高估了甲状腺摄取率(P<0.001);基于SPECT/CT定量评估参数与甲状腺激素水平具有相关性(P<0.05)。结论 SPECT/CT较传统的TUS能获得更精确的甲状腺摄锝率,对诊断甲状腺功能疾病具有重要临床指导价值。
Objective Often the traditional Thyroid Uptake System (TUS) cannot accurately measure taken technetium rate. This paper aimed to discusses the effectiveness of Single Photon Emission Computed Tomography (SPECT)/CT after injection of 99mTcO4 in detecting thyroid function abnormalities. Methods 60 patients of thyroid inspectors were analyzed retrospectively, including 20 cases of diffuse toxic goiter (Graves disease), 15 cases of thyroiditis and 25 cases of normal thyroid function. All patients were administered SPECT/CT after injection of 99mTcO4, calculating thyroid uptake rate and Standardized Uptake Value (SUV), 20 Graves disease and 15 thyroiditis patients accept traditional determination of TUS in the same period. Results SPECT/CT quantitative evaluation parameters (thyroid uptake rate, average and maximum of standard intake) largest in Graves disease, followed by thyroiditis, minimum thyroid function in normal (P<0.001); TUS significantly overestimated the thyroid uptake rate compared with SPECT/CT (P<0.001) because other 99mTcO4 sources in addition to thyroid contributed to the thyroid uptake rate result by TUS, whereas the SPECT/CT quantitative evaluation parameter with thyroid hormone levels has better correlation (P<0.05). Conclusion Quantitative SPECT/CT is more accurate than conventional TUS for measuring 99mTcO4 thyroid uptake rate, also has important clinical value in the diagnosis of thyroid function disease.
作者
刘任从
张乐乐
LIU Ren-cong;ZHANG Le-le(Department of Nuclear Medicine, Nanjing Hospital, Nanjing Medical University (Nanjing First Hospital), Nanjing Jiangsu 210006, China)
出处
《中国医疗设备》
2017年第4期79-82,共4页
China Medical Devices
