摘要
目的:系统评价文拉法辛与艾司西酞普兰治疗抑郁症的药物经济学效果。方法:以"文拉法辛""艾司西酞普兰""抑郁症""抑郁发作""抗抑郁"等作为关键词,计算机检索中国期刊全文数据库(CNKI)、维普中文期刊全文数据库(VIP)、万方医学数据库,检索时间为创库日期至2015年12月,筛选符合纳排标准的文拉法辛与艾司西酞普兰治疗抑郁症的相关文献。统计两组方案治疗抑郁症的痊愈率和汉密尔顿抑郁量表(HAMD)评分,并采用药物经济学中成本-效果分析法对其进行分析。结果:两组方案痊愈率和HAMD评分比较,差异均无统计学意义(P>0.05),故采用最小成本法进行分析。文拉法辛与艾司西酞普兰治疗抑郁症的成本分别为772.03、935.77元。结论:文拉法辛与艾司西酞普兰治疗抑郁症的疗效相当,但文拉法辛方案更为经济。
OBJECTIVE:To systematically evaluate the pharnacoeconomic effect of venlafaxine and escitalopram in the treatment of depressive disorders.METHODS:Using“venlafaxine”“escitalopram”“depression”“depressive episode”“antidepressant”as key words,retrieved from CNKI,VIP and Wanfang database during base creation date to Dec.2015,related literatures about venlafaxine and escitalopram in the treatment of depressive disorders were selected.The cure rate of two therapy plans for depressive disorders and HAMD score were analyzed statistically by cost-effectiveness analysis of pharnacoeconomics.RESULTS:There was no statistical significance in cure rate and HAMD score between2groups(P>0.05),so minimum-cost analysis was adopted.The costs of venlafaxine and escitalopram in the treatment of depressive disorders were772.03yuan and935.77yuan.CONCLUSIONS:Therapeutic efficacy of venlafaxine is similar to that of escitalopram in the treatment of depressive disorders,but the former scheme is more economical.
作者
杜彪
杜扬
谢星星
范小冬
张春燕
孔文强
DU Biao;DU Yang;XIE Xingxing;FAN Xiaodong;ZHANG Chunyan;KONG Wenqiang(Dept. of Pharmacy,Chongqing Three Gorges Central Hospital,Chongqing 404000,China;Grade 2012,Department One of Clinical Medicine,Chongqing Medical University,Chongqing 400016,China;School of Pharmacy,Southwest Medical University,Sichuan Luzhou 646000,China;School of Pharmacy,North Sichuan Medical College,Sichuan Nanchong 637000,China)
出处
《中国药房》
CAS
北大核心
2017年第11期1456-1459,共4页
China Pharmacy
基金
重庆市科技计划项目(cstc2015shmszx120073)
重庆市万州区科技计划项目(201403055)
关键词
文拉法辛
艾司西酞普兰
抑郁症
最小成本分析
循证药物经济学评价
Venlafaxine
Escitalopram
Depressive disorder
Cost-minimization analysis
Evidence-based pharnacoeconomic evaluation
