摘要
目的探讨肺血栓栓塞症(PTE)治疗中法舒地尔与那屈肝素钙联合治疗的临床价值。方法选取PTE患者60例,随机分为研究组和对照组,各30例,分别选择普通肝素联合华法林治疗以及法舒地尔联合那屈肝素钙治疗。结果治疗14 d后研究组患者的治疗显效率与总有效率均明显高于对照组(P<0.05)。治疗前两组患者呼吸频率、心率、Pa O2、Pa CO2比较差异均无统计学意义,治疗14 d后两组患者呼吸频率、心率均相比治疗前显著降低(P<0.01),Pa O2、Pa CO2均相比治疗前显著升高(P<0.01),研究组患者治疗后呼吸频率、心率均明显高于对照组(P<0.05),Pa O2显著高于对照组(P<0.01)。结论法舒地尔与那屈肝素钙联合治疗非大面积肺血栓栓塞症,能够显著提高治疗有效性,改善患者症状以及体征,安全性较高,适合推广应用。
Objective To investigate the pulmonary thromboembolism(PTE)clinical value of combined therapy of fasudil and nadroparin calcium.Methods60cases of39PTE patients were randomly divided into2groups,30cases each,were selected and heparin combined with Hua Falintherapy and fasudil combined with nadroparin calcium treatment.Results The effective rate and total effective rate of the treatment group were significantlyhigher than those in the control group(P<0.05),after the treatment of14d.Two groups of patients before treatment of respiratory frequency,heart rate,PaO2,PaCO2,there were no significant differences between the two groups of patients after treatment of14d,respiratory frequencyand heart rate were significantly lower than before treatment(P<0.01),PaO2and PaCO2were significantly increased compared with before treatment(P<0.01),frequency and heart rate were significantly higher than the control group respiratory research group(P<0.05),PaO2was significantlyhigher than the control group(P<0.01).Conclusion Fasudil and nadroparin calcium in the treatment of non massive pulmonary embolism,can significantly improve the treatment efficiency,improve symptoms and signs,high safety,suitable for application.
作者
王帮亚
杨红卫
张强
Wang Bang-ya;Yang Hong-wei;Zhang Qiang(Department of pharmacy, Pizhou Municipal People's Hospital, Pizhou, Jiangsu, 221300, China)
出处
《当代医学》
2017年第12期18-21,共4页
Contemporary Medicine
