摘要
目的分析鼠神经生长因子在治疗危重型小儿手足口病患者时对其体内细胞因子和体液免疫的干扰作用。方法以94例危重型小儿手足口病患者为探究对像。47例危重型小儿手足口病患者给予喜炎平注射液治疗的同时肌肉注射鼠神经生长因子作为观察组,及同期只给予喜炎平注射液治疗的47例危重型小儿手足口病患者作为对照组。于治疗前后同时检测两组患儿体内细胞因子指标(Ig A、Ig G、Ig M)和体液免疫的指标(CD8^+、CD4^+、CD4^+/CD8^+)的变化情况。并将两组所得的数据进行比较。结果治疗后两组患者体内三种细胞因子指标和三种体液免疫指标的浓度较治疗前均有明显提高(P<0.05),且观察组患者体内三种细胞因子指标和三种体液免疫指标的浓度显著高于对照组(P<0.05)。结论鼠神经生长因子可以提高危重型小儿手足口病患者体细胞因子及体液免疫因子的水平从而发挥更好的疗效。
Objective To analyze the interferential effect of mouse nerve growth factor on cell factor and humeral immunity in patients with severehand foot and mouth disease.Methods94patients with hand,foot and mouth disease were selected as the research object.47severe pediatricpatients with hand foot mouth disease in the observation group were treated with xiyanping injection and at the same time,the mouse nerve growthfactor was injected.And another47severe pediatric patients with hand foot mouth disease in the control group were treated with only xiyanping injection.Before and after treatment,the changes of cytokines(IgA,IgG,IgM)and humeral immunity indexes(CD8+,CD4+,CD4+/CD8+)in childrenwere detected in the two groups.And the data of the two groups were compared.Results After treatment,the concentrations of three cytokines andthree kinds of humeral immune indexes in the children in two groups were more significantly increased than those before treatment(P<0.05).In theobservation group,the concentration of three cytokines and three kinds of humeral immune indexes were significantly higher than those in the controlgroup(P<0.05).Conclusion The mouse nerve growth factor can improve the level of body and humeral immune factors in critical childrenwith hand foot and mouth disease,so as to play a better therapeutic effect.
作者
刘静
Liu Jing(The hospital of integrated traditional Chinese and western Medicine of Dazhou City in Sichuan, Dazhou, Sichuan, 635000, China)
出处
《当代医学》
2017年第12期38-40,共3页
Contemporary Medicine
关键词
鼠神经生长因子
危重型小儿手足口病
细胞因子
体液免疫
Mouse nerve growth factor
Severe hand foot and mouth disease
Cell factor
Humeral immunity
