摘要
目的研究足月新生儿坏死性小肠结肠炎(NEC)发生特征以及危险因素。方法 52例足月新生儿NEC患儿作为观察组,52例足月新生儿非NEC患儿作为对照组,分析两组的临床资料,观察足月新生儿NEC的发病特征及发病危险因素。结果两组患儿胃潴留、腹壁静脉显露红斑、肠穿孔、体温不稳、肌张力减低所占比例比较差异均无统计学意义(P>0.05),观察组患儿呕吐、腹胀、便血、肠鸣音减弱、皮肤苍灰所占比例(65.38%、61.54%、82.69%、73.08%、53.85%)明显高于对照组(30.77%、26.92%、23.08%、36.54%、25.00%),差异均具有统计学意义(P<0.05)。单因素结果显示,胎龄、生后窒息、母乳喂养、口服益生菌、败血症、毒性红斑、先天性心脏病、先天性肠道畸形、巨细胞病毒(CMV)均与足月新生儿NEC发病有关(P<0.05)。经Logistic多因素分析显示,生后窒息、败血症、先天性心脏病、先天性肠道畸形是引发足月新生儿NEC发病的危险因素(P<0.05);而母乳喂养、口服益生菌是足月新生儿NEC发病的保护因素(P<0.05)。结论足月新生儿NEC的发病危险因素与生后窒息、败血症、先天性心脏病、先天性肠道畸形有关,而对患儿进行母乳喂养以及口服益生菌可降低新生儿NEC发生的几率。
Objective To study the epidemiological features and risk factors of full-term neonatalnecrotizing enterocolitis(NEC).Methods There were52full-term NEC newborns as observation group,and52full-term non-NEC newborns as control group.Their clinical data were analyzed to observe the epidemiologicalfeatures and risk factors of full-term NEC newborns.Results Both groups had no statistically significantdifference in proportion of gastric retention,abdominal vein revealed erythema,bowel perforation,temperatureinstability,and muscle tension reduction(P>0.05).The observation group had obviously higher proportion ofvomiting,abdominal distension,hematochezia,hypoactive bowel sounds and pale gray skin(65.38%,61.54%,82.69%,73.08%and53.85%)than the control group(30.77%,26.92%,23.08%,36.54%and25.00%),and theirdifference had statistical significance(P<0.05).Single factor results showed that gestational age,asphyxia afterbirth,breastfeeding,oral probiotics,sepsis,erythema,congenital heart disease,congenital intestinal abnormalities,cytomegalovirus(CMV)were all correlated to full-term neonatal NEC occurrence(P<0.05).Logistic multiplefactoranalysis showed that asphyxia after birth,sepsis,congenital heart disease,congenital intestinal abnormalitieswere risk factors induced full-term neonatal NEC occurrence(P<0.05)and breastfeeding and oral probiotics wereprotect factors for full-term neonatal NEC occurrence(P<0.05).Conclusion Risk factors of full-term neonatalNEC occurrence are correlated to after birth,sepsis,congenital heart disease,congenital intestinal abnormalities,and breastfeeding and oral probiotics can reduce incidence of neonatal NEC.
作者
杜桂莲
许艳
许玲
DU Gui-lian;XU Yan;XU Ling(Department of Neonatology, Shenzhen City Baoan District Fifth People’s Hospital,Shenzhen 528105, China)
出处
《中国现代药物应用》
2017年第9期22-24,共3页
Chinese Journal of Modern Drug Application
关键词
坏死性小肠结肠炎
足月新生儿
发生特征
危险因素
Necrotizing enterocolitis
Full-term neonatal
Epidemiological features
Risk factors
