摘要
目的:探讨西归乙醇提取物对缩宫素诱发小鼠痛经的镇痛作用。方法:己烯雌酚与缩宫素联用建立痛经模型,观察不同浓度西归乙醇提取物的镇痛作用。末次给药1 h后,制备子宫匀浆,测定SOD活性,MDA、NO和Ca2+的含量。结果:西归乙醇提取物能显著降低缩宫素引起的扭体反应,能明显提高子宫匀浆中SOD的活性,降低MDA、升高NO和降低Ca2+的含量(P<0.05或P<0.01)。结论:西归乙醇提取物对小鼠原发性痛经有明显的镇痛作用,其作用机制可能是通过影响SOD、MDA、NO、Ca2+而实现的。
Objective:To investigate the analgesic effect of ethanol extract from the seselopsis to the primary dysmenorrhea induced by oxytocin in mice.Methods:A dysmenorrhea model combining diethylstilbestrol and oxytocin was used to observe the effect of different concentrations of seselopsis ethanol extract and aspirin.About1h after the last medication,the uterine homogenate was prepared,and the content of SOD activity,MDA,NO and Ca2+were determined.Results:The ethanol extract from seselopsis could significantly reduce the writhing response induced by oxytocin,which could significantly improve the activity of SOD,decrease the content of MDA,increase NO and decrease the content of Ca2+(P<0.05or P<0.01).Conclusion:The ethanol extract of seselopsis has obvious analgesic effect on primary dysmenorrhea in mice.
作者
周启微
郭美仙
杨佳晶
卢明
金雪军
沈磊
刘晓波
Zhou Qiwei;Guo Meixian;Yang Jiajing;Lu Ming;Jin Xuejun;Shen Lei;Liu Xiaobo(College of Pharmacy and Chemistry, Dali University, Dali, Yunnan 671000, China)
出处
《大理大学学报》
CAS
2017年第4期24-27,共4页
Journal of Dali University
基金
大理大学大学生科研基金资助项目(KYSX2015098)
关键词
西归
痛经
超氧化物歧化酶
丙二醛
一氧化氮
钙离子
seselopsis
dysmenorrhea
superoxide dismutase
malondialdehyde
nitric oxide
calcium ion
