摘要
目的探讨左甲状腺素钠片对妊娠并甲状腺功能减退症(甲减)孕妇血清同型半胱氨酸(Hcy)、超氧化物歧化酶(SOD)水平的影响。方法 90例妊娠合并甲减患者为研究对象,将患者随机分为对照组和研究组,每组45例。对照组患者采用基础药物进行治疗,研究组患者使用左甲状腺素钠片进行治疗,比较两组患者治疗前后的血清Hcy和SOD水平变化情况。结果治疗后,研究组患者Hcy水平为(13.23±2.62)μmol/L,SOD水平为(173.64±32.21)U/ml;对照组患者Hcy水平为(16.92±3.41)μmol/L,SOD水平为(152.62±25.17)U/ml。两组患者治疗后的血清Hcy水平均明显低于治疗前,SOD水平均显著高于治疗前,差异均具有统计学意义(P<0.05)。研究组患者的血清Hcy水平和SOD水平变化均优于对照组,差异有统计学意义(P<0.05)。结论妊娠合并甲减孕妇采用左甲状腺素钠片治疗,能够使患者的血清Hcy水平和SOD水平恢复至正常值,具有良好的临床疗效,值得临床进行推广和应用。
Objective To investigate influence by levothyroxine sodium tablets on serum homocysteine(Hcy)and superoxide dismutase(SOD)levels in pregnant women with hypothyroidism.Methods A total of90pregnant women with hypothyroidism as study subjects were randomly divided into control group and researchgroup,with45cases in each group.The control group received basic drug therapy,and the research group receivedlevothyroxine sodium tablets for treatment.Comparison was made on serum Hcy and SOD levels before and aftertreatment between the two groups.Results After treatment,the research group had Hcy level as(13.23±2.62)μmol/Land SOD level as(173.64±32.21)μmol/L,and the control group had Hcy level as(16.92±3.41)μmol/L andSOD level as(152.62±25.17)μmol/L.Both groups had obviously lower serum Hcy and higher SOD levels aftertreatment than those before treatment,and their differences all had statistical significance(P<0.05).The researchgroup had much better improvement of serum Hcy and SOD levels than the control group,and the difference hadstatistical significance(P<0.05).Conclusion Implement of levothyroxine sodium tablets in treating pregnantwomen with hypothyroidism can recover serum Hcy and SOD levels in patients,along with excellent clinical effect.This method is worth clinical promotion and application.
作者
黄森强
陈秀霞
罗红莲
HUANG Sen-qiang;CHEN Xiu-xia;LUO Hong-lian(Guangdong Xingning City Maternal and Child Health Care Hospital, Xingning 514500, China)
出处
《中国现代药物应用》
2017年第10期103-104,共2页
Chinese Journal of Modern Drug Application
