摘要
目的探讨肿瘤标志物检验应用于肺癌筛查与诊断中的临床价值。方法以35例经病理检查确诊为肺癌的患者作为研究对象,将其设为观察A组,同时选取同期确诊为良性肺部病变者35例作为观察B组,及同期进行健康体检者35例作为对照组,对比3组患者血清中肿瘤标志物神经元特异性烯醇化酶(neuron specific enolase,NSE)、血清癌胚抗原(carcinoembryonic antigen,CEA)、细胞角蛋白19片段(CYFRA21-1)、鳞癌相关抗原(squamous cell carcinoma associated antigen,SCC-Ag)水平。结果观察A组血清肿瘤标志物NSE、CEA、CYFRA21-1、SCC-Ag水平明显高于观察B组和对照组,差异均有统计学意义(P<0.05);观察B组血清肿瘤标志水平与对照组比较,差异无统计学意义(P>0.05)。结论肿瘤标志物水平是临床诊断肺癌的重要参考依据,其敏感度高,对肺癌筛查与诊断具有较高应用价值。
Objective To investigate the clinical value of tumor markers in the screening and diagnosisof lung cancer.Methods A total of35patients with lung cancer confirmed by pathological examinationwere enrolled in this study,and the patients were divided into observation group A.35patients with benignlung disease were selected as the observation group B.35healthy subjects were taken as the control group.Theserum levels of tumor specific markers of neuron specific enolase(NSE),serum carcinoembryonic antigen(CEA),cytokeratin19fragment(CYFRA21-1)and squamous cell carcinoma associated antigen(SCC-Ag)were comparedamong the3groups.Results The serum tumor markers of NSE,CEA,CYFRA21-1,SCC-Ag levels in the A groupwere significantly higher than those in the B group and the control group,all with significant differences(P<0.05).The serum tumor markers in the B group were compared with the control group,and the difference was not statisticallysignificant(P>0.05).Conclusion The level of tumor markers is an important reference for clinical diagnosisof lung cancer,and its sensitivity is high,which has a high application value in the screening and diagnosisof lung cancer.
作者
谭邈渊
Miaoyuan TAN(Hankou Hospital, Hankou 430000, China)
出处
《临床检验杂志（电子版）》
2016年第3期174-176,共3页
Clinical Laboratory Journal(Electronic Edition)
关键词
肺肿瘤
肿瘤标志物
诊断价值
Lung neoplasms
Tumor markers
Diagnostic value
