摘要
目的:探讨启宫丸汤联合化学药对多囊卵巢综合征(PCOS)合并不孕症患者激素水平的影响。方法:选取2015年7月-2016年6月于我院妇科就诊的PCOS合并不孕症患者98例为研究对象,采用随机数字表法分为观察组和对照组,各49例。对照组患者于月经第5天起口服枸橼酸氯米芬片50 mg,qd,连续5 d;于月经第11天行B超监测卵泡发育情况,若无直径>10 mm的优势卵泡则肌内注射注射用绒促性素2 000 U,隔日1次,至卵泡发育直径达18 mm。观察组患者在对照组基础上加用启宫丸汤,每日1剂,水煎取汁400 m L,早晚各服200 m L。治疗3个月后,比较两组患者血清卵泡刺激素(FSH)、黄体生成素(LH)、泌乳素(PRL)、雌二醇(E2)、总睾酮(T)、硫酸脱氢表雄酮(DHEA-S)、性激素结合球蛋白(SHBG)水平,以及子宫内膜厚度、成熟卵泡数量和妊娠率。结果:治疗前,两组患者FSH、LH、PRL、E2、T、DHEA-S、SHBG水平比较,差异均无统计学意义(P>0.05)。治疗3个月后,两组患者PRL、T、DHEA-S水平显著降低,E2、EHBG水平显著升高;且观察组患者FSH、PRL、T、DHEA-S水平显著低于对照组,E2、SHBG水平显著高于对照组,差异均有统计学意义(P<0.05)。观察组患者子宫内膜厚度明显大于对照组,妊娠率(18.37%)明显高于对照组(4.08%),差异均有统计学意义(P<0.05)。结论:启宫丸汤联合化学药治疗PCOS合并不孕症,有助于调节患者血清激素水平、提高妊娠率。
OBJECTIVE:To investigate the effects of Qigong pills decoction combined with chemical drugs on hormone levelsof polycystic ovarian syndrome(PCOS)patients complicated with infertility.METHODS:A total of98PCOS patients complicatedwith infertility selected from gynaecology department of our hospital during Jul.2015-Jun.2016were divided into observationgroup and control group according to random number table,with49cases in each group.Control group was given Clomiphene citratetablet50mg orally,qd,for consecutive5d;B-ultrasonography for follicle development was monitored at the11th day ofmenstruation,and then they were given Chorionic Gonadotropin for injection2000U intramuscularly,qod,if there was not dominantfollicle>10mm till the diameter of follicle reached18mm.Observation group was additionally given one dose of Qigongpills decoction,every day400mL after decocted with water,each200mL for morning and night,on the basis of control group.After3months of treatment,the levels of FSH,LH,PRL,E2,T,DHEA-S and SHBG,the endometrial thickness,the number ofmature follicle and pregnancy rate were compared between2groups.RESULTS:Before treatment,there was no statistical significancein the levels of FSH,LH,PRL,E2,T,DHEA-S or SHBG between2groups(P>0.05).3months after treatment,the levelsof PRL,T and DHEA-S in2groups were decreased and E2,SHBG were increased significantly;the levels of FSH,PRL,Tand DHEA-S in observation group were significantly lower than control group,while the levels of E2and SHBG were significantlyhigher than control group,with statistical significance(P<0.05).Endometrial thickness of observation group were significantly higher than that of control group;pregnancy rate(18.37%)was significantly higher than control group(4.08%),with statisticalsignificance(P<0.05).CONCLUSIONS:Qigong pills decoction combined with chemical drugs can help to improve pregnancyrate and regulate serum hormone level in the treatment of PCOS complicated with infertility.
作者
赵凤英
赵惠芬
马梅
徐艳
ZHAO Fengying;ZHAO Huifen;MA Mei;XU Yan(Gynecologist Clinic,Zunyi Traditional Chinese Medical Hospital,Guizhou Zunyi 563000,China;Dept. of Obstetrics and Gynecologist,Zunyi Traditional Chinese Medical Hospital,Guizhou Zunyi 563000,China;Dept. of Medicine,Zunyi Traditional Chinese Medical Hospital,Guizhou Zunyi 563000,China;Dept. of Outpatient,Zunyi Traditional Chinese Medical Hospital,Guizhou Zunyi 563000,China)
出处
《中国药房》
CAS
北大核心
2017年第17期2416-2418,共3页
China Pharmacy
关键词
多囊卵巢综合征
不孕症
启宫丸汤
血清激素水平
妊娠率
Polycystic ovarian syndrome
Infertility
Qigong pills decoction
Serum hormone levels
Pregnancy rate
