摘要
目的探讨小剂量右美托咪定对宫颈癌微创术后胃肠道反应的影响。方法选取2014年2月-2016年9月在该院接受宫颈癌微创术的患者94例,依据随机数表法分为观察组(小剂量右美托咪定)和对照组(生理盐水),比较两组患者的恶心、呕吐发生率及胃动素水平。结果观察组47例,Ⅱ级恶心7例,Ⅲ级恶心2例,总发生率为19.15%;对照组47例,Ⅱ级恶心11例,Ⅲ级恶心4例,Ⅳ级恶心2例,总发生率为36.17%,差异具有统计学意义(P<0.05)。观察组47例,Ⅱ级呕吐6例,Ⅲ级呕吐1例,总发生率为14.89%;对照组47例,Ⅱ级呕吐4例,Ⅲ级呕吐5例,Ⅳ级呕吐1例,总发生率为21.28%,差异具有统计学意义(P<0.05)。术前1 h两组患者的胃动素差异无统计学意义(P>0.05)。术后6、12和24 h,观察组患者的胃动素水平明显低于对照组,差异具有统计学意义(P<0.05)。结论小剂量右美托咪定能够有效预防和缓解宫颈癌微创术后胃肠道反应,避免胃动素过度释放,值得临床推广。
Objective To investigate the effect of low dose Dexmedetomidine on gastrointestinal reaction after minimally invasive surgery for cervical cancer.Methods94patients with cervical cancer treated with minimally invasive surgery from February2014to September2016were selected.According to the random number table method,the patients were divided into observation group(low-dose Dexmedetomidine)and control group(saline).The incidence of nausea and vomiting,the motilin level were compared between the two groups.Results The observation group was47cases,gradeⅡnausea in7cases,gradeⅢnausea in2cases,the total incidence was19.15%;47cases in the control group,11cases of gradeⅡnausea,gradeⅣnausea in4cases,grade2nausea in2cases,the rate was36.17%,the difference was statistically significant(P<0.05).47cases of gradeⅡvomiting in4cases,gradeⅢvomiting in5cases,gradeⅣvomiting in1case,the total incidence rate was14.89%,gradeⅡin4case,gradeⅢvomiting in5cases,gradeⅣvomiting in1case,the total incidence was21.28%,the difference was statistically significant(P<0.05).There was no significant difference in motilin level between the two groups(P>0.05).At6h,12h and24h after operation,the levels of motilin in the observation group were significantly lower than those in the control group,the difference was statistically significant(P<0.05).Conclusion Low dose Dexmedetomidine can effectively prevent and alleviate the gastrointestinal reaction after minimally invasive surgery for cervical cancer,and avoid the excessive release of motilin,worthy of clinical promoting.
作者
张彩玲
廖婷
罗莹嘉
范思苑
Cai-ling Zhang;Ting Liao;Ying-jia Luo;Si-yuan Fan(Department of Anesthesiology, Traditional Chinese Medicine Hospital, Meizhou,Guangdong 514031, China)
出处
《中国内镜杂志》
北大核心
2017年第7期76-79,共4页
China Journal of Endoscopy
关键词
右美托咪定
宫颈癌
胃肠道反应
Dexmedetomidine
cervical cancer
gastrointestinal reactions
