摘要
目的探讨前列地尔治疗高龄糖尿病并慢性肾脏病患者疗效与安全性。方法在医院2015年4月~2016年3月期间诊治的高龄糖尿病并慢性肾脏病患者中抽取54例作研究对象并采用随机抽签方式分组,对照组(n=27)采取常规综合疗法,治疗组(n=27)则在常规综合疗法基础上加用前列地尔治疗,对比两组患者临床疗效以及不良反应发生率。结果治疗组患者的治疗总有效率是92.6%,远高于对照组患者的70.4%(P<0.05);治疗后治疗组24 h尿蛋白排泄率是(244.9±10.4)mg/min,低于对照组的(252.1±13.9)mg/min(P<0.05);治疗组不良反应发生率是14.8%,对照组不良反应发生率是11.1%,其对比差异无统计学意义。结论前列地尔治疗高龄糖尿病并慢性肾脏病患者疗效显著,且安全性较高,可作为高龄糖尿病并慢性肾脏病患者的首选用药方案。
Objective To investigate the efficacy and safety of alprostadil in the treatment of elderly patients with diabetes mellitus and chronic kidney disease.Methods Fifty-four elderly patients with diabetes mellitus and chronic kidney disease who were treated between April2015and March2016were randomly divided into two groups:control group(n=27)and conventional therapy group(n=27)in the conventional comprehensive therapy based on the use of alprostadil treatment,compared with two groups of patients with clinical efficacy and the incidence of adverse reactions.Results The total effective rate was92.6%in the treatment group,which was significantly higher than that in the control group(P<0.05).After24hours of treatment,the urinary protein excretion rate was(244.9±10.4)mg/min,(252.1±13.9)mg/min(P<0.05).The incidence of adverse reactions was14.8%in the treatment group and11.1%in the control group,the difference was not statistically significant.Conclusion The treatment of elderly patients with diabetes mellitus and chronic kidney disease is effective and safe,and it can be used as the preferred drug regimen for elderly patients with diabetes mellitus and chronic kidney disease.
作者
饶盛环
Rao Sheng-huan(Department of Hematology, the First People's Hospital of Fuzhou City, Fuzhou,Jiangxi,344000, China)
出处
《当代医学》
2017年第21期75-76,共2页
Contemporary Medicine
关键词
前列地尔
高龄糖尿病并慢性肾脏病
安全性
Alprostadil
Elderly diabetes mellitus and chronic kidney disease
Safety
