摘要
研究偏碱性恩诺沙星注射液对SD大鼠的长期毒性作用,揭示其临床安全性。连续给药70,d后,与对照组相比,偏碱性恩诺沙星注射液试验组大鼠的血常规及各项血液生化检测指标均无显著差异。病理组织学检查发现偏碱性恩诺沙星注射液各药物组与对照组相比,除偏碱性恩诺沙星注射液100,m L/kg剂量组大鼠的肝脏和肾脏出现轻微的组织损伤外,50,m L/kg和25,m L/kg剂量组SD大鼠的各组织器官均无明显组织病理学变化。因此偏碱性恩诺沙星注射液毒性较弱,连续腹腔注射情况下对SD大鼠无不良影响。
The subchronic toxicity of alkali deviation type enrofloxacin injection in SD rats is studied by continuous perfusionin order to expose its clinical innocuity.80SD rats(male and female)were randomly divided into the control group withnormal saline NS and alkali deviation type enrofloxacin injection in3different dosage groups(100,50and25,mL/kg,20,in each group).The SD rats were administered with alkali deviation type enrofloxacin injection by continuous perfusionfor10,weeks.After70,days,contrasted with the control group,the test group rats’blood routine examination index andblood index had no approximate difference.The result of histopathological slices showed that the liver and kidney of alkalideviation type enrofloxacin injection100,mL/kg group rats appeared slight damage,while the organs of alkali deviationtype enrofloxacin injection500,mL/kg group rats and25,mL/kg group dose did not find obvious histopathologic change.Thealkali deviation type enrofloxacin injection has little toxic effect so that there is no harmful effect on SD rats throughintraperitoneal injection.
作者
王立红
刘芳
管振国
张俊霞
李源
刘鼎阔
WANG Lihong;LIU Fang;GUAN Zhen’guo;ZHANG Junxia;LI Yuan;LIU Dingkuo(Enterprise Key Laboratory of Feed Microbial Preparation,Tianjin 300383,China;S&E Animal Pharmaceutical(Tianjin)Co.,Ltd.,Tianjin 300383,China;College of Veterinary Medicine at CAU,Beijing 100094,China)
出处
《天津科技》
2017年第7期49-52,55,共5页
Tianjin Science & Technology
基金
国家农业科技成果转化资金项目(2013GB2A100020)
天津市科技支撑资金项目(13ZCZDNC00700)
关键词
偏碱性恩诺沙星注射液
大鼠
亚慢性毒性
alkali deviation type enrofloxacin injection
SD rat
subchronic toxicity
