摘要
目的探讨狼疮性肾炎患者血清白介素-6、白介素-10水平及临床意义。方法选择2014年1月~2016年6月在我院诊断为狼疮性肾炎患者40例为实验组,其中20例患者处于活动期,缓解期患者20例,另选择同期健康体检志愿者20例为对照组。检测三组血清IL-6及IL-10水平。结果实验组活动期IL-6及IL-10水平显著高于缓解期及对照组,差异有统计学意义(P<0.05)。缓解期IL-6及IL-10水平显著高于对照组,差异有统计学意义(P<0.05)。实验组活动期Trge水平显著低于缓解期以及对照组,差异有统计学意义(P<0.05);实验组活动期CD19+CD69+显著高于缓解期以及对照组,缓解期显著高于对照组,差异有统计学意义(P<0.05)。结论狼疮性肾炎活动期患者血清IL-6、IL-10以及B淋巴细胞水平显著升高,Treg水平下降,其可以作为临床判断狼疮性肾炎活动程度的相关指标。
Objective To explore levels and clinical significance of serum interleukin-6and interleukin-10ofpatients with lupus nephritis.Methods40patients who were diagnosed as lupus nephritis in our hospital fromJanuary2014to June2016were selected as the experimental group.Among whom,20patients were in active stage and20patients were in remission stage.20healthy volunteers during the same period were selected as the control group.Serum interleukin-6and interleukin-10levels of three groups were detected.Results Serum interleukin-6andinterleukin-10levels in active stage of the experimental group were higher than those in remission stage and thoseof the control group.The difference was statistically significant(P<0.05).Serum interleukin-6and interleukin-10levels in remission stage were significantly higher than those of the control group.The difference was statisticallysignificant(P<0.05).Trge level in active stage of the experimental group was significantly lower than that of theremission stage and the control group.The difference was statistically significant(P<0.05).CD19+CD69+in activestage of the experimental group was significantly higher than that of the remission stage and that of the control group.And the remission was significantly higher than the control group.The difference was statistically significant(P<0.05).Conclusion Levels of serum IL-6,IL-10and B lymphocyte of patients with lupus nephritis are significantly increasedwhile Treg was decreased.They can be regarded as related index to judge the activity of lupus nephritis in clinic.
作者
黄欢
HUANG Huan(Guangning People's Hospital,Guangning 526300,China)
出处
《中国医药科学》
2017年第13期248-250,253,共4页
China Medicine And Pharmacy
