摘要
肿瘤之治关键在于明辨邪正之强弱,以相应取法来扶正与祛邪。在肿瘤治疗中,补益气血方剂的扶正固本作用是中医药治疗肿瘤的优势之一。具有扶正固本,增效减毒作用的当归补血汤在抗肿瘤治疗中占有举足轻重的地位。为此,以实验研究发展的时间先后顺序为主线,介绍其抗肿瘤作用的发展历程和研究现状,其结果表明,无论是单独使用当归补血汤,还是与其他药物联合或与其他方剂合用均表现出一定的抗肿瘤作用。故综合分析梳理当归补血汤的增效减毒与机体保护、抑制肿瘤转移、抑制肿瘤细胞增殖和诱导肿瘤细胞凋亡、影响肿瘤细胞膜代谢、影响肿瘤细胞信号通路转导、影响肿瘤细胞端粒酶活性等6个方面的抗肿瘤作用的机制,并对当归补血汤的发展前景给予展望,为后续研究提供必要的文献参考。
The key lies in the treatment of tumor is to clearly discriminate the strong and weak of evil and positive,and the corresponding method was used to support positive and eliminate evil.The function of supporting healthy energy of invigorating qi and blood prescription was one of the advantages for treating cancer by using Chinese medicine.Angelicae Sinensis Decoction for Supplementing Blood possessed the function of supporting healthy energy and effect-enhancing and toxicity-reducing,and it was a pivotal role in antitumor treatment.Therefore,the chronological order of experimental research was adopted as the main line,the development and research status of anti-tumor effect were introduced in this paper,the results showed that single use of the Angelicae Sinensis Decoction for Supplementing Blood,and the combination with other drugs or other prescriptions have antitumor effect in some degree.Depended on above reasons,the comprehensive analysis of antitumor mechanism of Angelicae Sinensis Decoction for Supplementing Blood included6aspects:effect-enhancing and toxicity-reducing and protecting body:inhibited tumor metastasis,inhibited proliferation of tumor cell and induced apoptosis of tumor cell,affected the metabolism of tumor cell membranes,affected the transduction of signaling pathways of tumor cell,and affected the telomerase activity of tumor cell.Besides,this paper took a prospection for the development of Angelicae Sinensis Decoction for Supplementing Blood and provided necessary reference documents for subsequent researches.
作者
王艳杰
康芯荣
张雨薇
孙阳
代巧妹
WANG Yan-jie;KANG Xin-rong;ZHANG Yu-wei(School of Basic Medicine, Heilongjiang University Of Chinese Medicine, Harbin 150040, China)
出处
《中国医学装备》
2017年第8期165-169,共5页
China Medical Equipment
基金
2012黑龙江省博士后科学基金(LBH-Z12258)"夏莲花汤对乳腺癌抗肿瘤作用及活性物质的拆方与配伍研究"
2013中国博士后(54批)科学基金(2013M541427)"不同配伍对白花蛇舌草抗肿瘤作用及化学成分的比较研究"
关键词
当归补血汤
肿瘤
进展
机制
Angelicae Sinensis Decoction for Supplementing Blood
Cancer
Progress
Mechanism
