摘要
目的:探讨婴幼儿牛奶蛋白过敏症的诊断方法,并进行Meta分析。方法:使用计算机检索中国知网、万方数据知识服务平台、中国生物医学文献数据库、维普中文期刊服务平台、Pub Med、Cochrane图书馆中关于婴幼儿牛奶蛋白过敏症诊断的文献,检索时间范围在2005-2016年,筛选出采用诊断方法相同的文献,探讨诊断方法的应用价值。结果:(1)经检索共获得12篇应用牛奶蛋白激发试验诊断婴幼儿牛奶蛋白过敏症的文献,其中5篇不符合纳入标准。(2)Meta分析结果显示,各篇文献中牛奶蛋白激发试验诊断婴幼儿牛奶蛋白过敏症的阳性率均>55%。(3)各篇文献中患儿的临床表现包括胃肠道症状、皮肤症状、呼吸道症状、全身症状等。结论:牛奶蛋白激发试验在婴幼儿牛奶蛋白过敏症的诊断中具有重要价值,建议医师联合使用其他方法对牛奶蛋白过敏症患儿实施诊断,以进一步提高诊断准确率。
Objective:To explore the diagnostic methods of milk protein allergy in infants and children,and to make meta analysis.Methods:We searched the literature on the diagnosis of milk protein allergy in infants and young children in Chinese CNKI,Wanfang data knowledge service platform,China biomedical literature database,VIP journals Chinese service platform,PubMed,Cochrane Library by computer,the search time ranges from2005to2016.We screened the literature using the same diagnosticmethod and explored the value of diagnostic methods.Results:①A total of12papers were published using milk proteinprovocation tests to diagnose milk protein allergy in infants and children,5of them did not meet the inclusion criteria.②Metaanalysis showed that the positive rates in each document of milk protein provocation tests to diagnose milk protein allergy ininfants and children were higher than55%.③The clinical manifestations of the patients included gastrointestinal symptoms,skinsymptoms,respiratory symptoms,systemic symptoms.Conclusion:The milk protein provocation test played an important role in thediagnosis of milk protein allergy in infants and children.We recommend that physicians combined use other methods to diagnosechildren with milk protein allergy to further improve the diagnostic accuracy.
作者
叶志英
陈德晖
杨少灵
袁吉丽
Ye Zhiying;Chen Dehui;Yang Shaoling;Yuan Jili(The First Affiliated Hospital of Guangzhou Medical University,510120)
出处
《中国社区医师》
2017年第24期65-66,68,共3页
Chinese Community Doctors
