摘要
目的观察厄贝沙坦联合苯磺酸氨氯地平治疗老年糖尿病合并高血压伴高尿酸血症患者的治疗效果。方法 60例糖尿病合并高血压伴高尿酸血症老年住院患者,按照治疗方式的不同将其分为研究组与对照组,每组30例。对照组患者给予苯磺酸氨氯地平治疗,研究组患者在对照组基础上联合厄贝沙坦治疗,对比两组患者的治疗效果、血压水平、血清尿酸水平以及不良反应情况。结果研究组患者治疗总有效率为93.33%,明显高于对照组的73.33%,差异具有统计学意义(P<0.05)。研究组患者的血压和血清尿酸水平改善情况明显优于对照组,差异具有统计学意义(P<0.05)。两组患者不良反应发生率对比差异无统计学意义(P>0.05)。结论厄贝沙坦联合苯磺酸氨氯地平治疗老年糖尿病合并高血压伴高尿酸血症的临床效果显著,能够改善患者的血压和血清尿酸水平,且联合用药的不良反应与单纯用药相同,安全性较高,值得推广使用。
Objective To observe the treatment effect of irbesartan combined with amlodipine besylatein the treatment of senile diabetes mellitus patients complicated with hypertension and hyperuricemia.Methods A total of60senile diabetes mellitus inpatients complicated with hypertension and hyperuricemia weredivided by different treatment methods into research group and control group,with30cases in each group.Thecontrol group was treated with amlodipine besylate,and the research group was treated with irbesartan on the basisof the control group.Comparison were made on treatment effect,blood pressure,serum uric acid levels and adversereactions condition in two groups.Results The research group had obviously higher total treatment effective rateas93.33%than73.33%in the control group,and the difference was statistically significant(P<0.05).The researchgroup had obviously better improvement of blood pressure and serum uric acid levels than the control group,and the difference was statistically significant(P<0.05).Both groups had no statistically significant difference inincidence of adverse reactions(P>0.05).Conclusion Combination of irbesartan and amlodipine besylate providesremarkable clinical effect in treating senile diabetes mellitus complicated with hypertension and hyperuricemia,and it can improve the blood pressure and the serum uric acid level of the patients.The side effects of combinedtherapy are the same as the simple medication,and the safety is high.So it is worth popularizing and using.
作者
张宁萍
ZHANG Ning-ping(Jiangsu Zhongshan Cadre Sanatorium, Nanjing 210014, China)
出处
《中国现代药物应用》
2017年第18期72-73,共2页
Chinese Journal of Modern Drug Application
