摘要
目的探讨异体输血对血管内皮生长因子表达水平的影响。方法采用ELISA方法检测120例输血前及输血后患者血清血管内皮生长因子(vascular endothelial growth factor,VEGF)含量,并分析其变化。结果输血后女性患者血清VEGF水平高于男性(P<0.05),差异有统计学意义,而年龄和血型与VEGF水平无相关性;输血后VEGF水平低于输血前,差异有统计学意义(P<0.01)。结论输血后血清血管内皮生长因子含量降低,提示输入的血制品可能会抑制VEGF表达。
Objective To investigate the influence of blood transfusion on serum levels of vascular endothelial growth factor(VEGF).Methods One hundred and twenty patientswere detected and analyzed for VEGF levels with SPSS17.0softwarebefore or after transfusion.Results The VEGF level of females was found to be significantly higher than that of males following blood transfusion(P<0.05).No difference was noted in age and blood group.It was fund that the VEGF expression of all subjects investigated seems to be decreased after transfusion compared with those before transfusion.(P<0.01).Conclusion The VEGF level in the sera of patients was reduced after transfusion,suggesting a possible inhibition of VEGF expression following transfused blood products.
作者
朱翔
韩凌飞
刘伟红
武萍
夏慧新
胡晓武
李之珍
ZHU Xiang;HAN Ling-Fei;LIU Wei-Hong(Maanshan Clinical Laboratory Center,Maanshan 243000)
出处
《临床输血与检验》
CAS
2017年第5期424-426,共3页
Journal of Clinical Transfusion and Laboratory Medicine
基金
安徽省马鞍山市科技攻关项目(No.YL-2014-09)资助
关键词
输血
血管内皮生长因子
血型
Blood transfusion
Vascular endothelial growth factor
Blood group
