摘要
目的观察兰索拉唑在胃食管反流患者中的临床效果及对食管动力学的影响状态.方法选取2015年10月至2016年8月期间曲靖市第一人民医收治的76例胃食管反流患者为研究对象,将76例患者随机分为对照组(奥美拉唑组)38例和观察组(兰索拉唑组)38例,然后将2组患者治疗后的总有效率、治疗前后的症状体征评分及食管动力学指标进行统计学处理.结果观察组治疗后的总有效率显著地高于对照组(P<0.05),治疗前2组患者的症状体征评分及食管动力学指标差异无统计学意义(P>0.05),而治疗后观察组的症状体征评分及食管动力学指标均好于对照组(P<0.05).结论兰索拉唑在胃食管反流患者中的临床效果较好,且可改善此类患者的症状体征及食管动力学状态,有临床应用价值.
Objective To observe the clinical effect of lansoprazole on the patients with gastroesophageal refluxand the influence on the esophageal dynamics.Methods Seventy-six patients with gastroesophageal reflux in ourhospital from October2015to August2016were set as the study object,and76patients were randomly divided intocontrol group(omeprazole group)and observation group(lansoprazole group),38cases in each group,then thetotal effective rates,symptoms and signs score and esophageal dynamics indexes of patients in two groups before andafter the treatment were respectively analyzed.Results The total effective rate of observation group was significantlyhigher than the rate of control group(P<0.05),the symptom and sign score and esophageal dynamics indexes oftwo groups before the treatment had no significantly differences(P>0.05),while the symptom and sign score andesophageal dynamics indexes of observation group after the treatment were all better than those of control group(P<0.05).Conclusion The clinical effect of lansoprazole in the patients with gastroesophageal reflux is better,and itcan significantly improve the symptoms and signs and esophageal dynamics state,so its clinical application value ishigher.
作者
张雪芹
徐晓林
ZHANG Xue-qin;XU Xiao-lin(Dept. of Gastroenterdogy,Qujing city first People’s Hospital,Qujing Yunnan 655000;College of Chemistry and Environmental Science,Qujing Normal University,Qujing Yunnan 655011)
出处
《昆明医科大学学报》
CAS
2017年第4期76-79,共4页
Journal of Kunming Medical University
基金
云南省教育厅科学研究基金资助项目(2016ZZX207)
关键词
兰索拉唑
胃食管反流
临床效果
食管动力学
Lansoprazole
Gastroesophageal reflux
Clinical effect
Esophageal dynamics
