摘要
目的探讨采用康复新液辅助联合放射治疗肺恶性肿瘤发生急性放射性食管炎的发生率及相关危险因素。方法选取2014年1月～2015年12月山西省中医院收治的107例接受康复新液辅助调强适形放疗（intensitymodulatedradiationtherapy，IMRT）治疗的肺部恶性肿瘤患者，按照RTOG标准统计急性放射性食管炎的发生率；同时用Logistic多元回归法分析患者性别、年龄、病理分型、肿瘤临床分期、放疗总时间、食管受照最大剂量、中位剂量和最小剂量、有效射野数目、有效射野比、有效野瘤皮距中位数、食管受照体积、V20、V30、V40、V50与急性放射性食管炎的相关性。结果入组病例共107例，其中发生放射性食管炎44.8%（48/107）；发生放射性食管炎的中位剂量24Gy，按照每周5次的常规放疗方案，发生放射性食管炎的初始时间一般在放疗开始后第3周。Logistic多元回归法分析只有V50进入方程，V50进入回归方程后OR=1.047，95%CI:1.021～1.074，P＜0.001。结论康复新液辅助放疗肺部恶性肿瘤具有降低或延迟放射性食管炎发生的效果。在各项统计指标中只有V50为发生放射性食管炎的独立危险因素。
Objective To analyze the incidence of radiation esophagitis(RE)esophagitis and the factors as predictors for acute radiation esophagitis in the treatment of kangfuxin solution combined with intensity modulated radiation therapy(IMRT)for lung neoplasms.Methods107patients presented with lung neoplasms received radiation and kangfuxin solution were collected,the occurrence rate of RE were analyzed according to RTOG standard and the relationship between RE and clinical and physical factors were analyzed by Logistic multivariate regression.Results Among the107cases of lung neoplasms recived radiation,the total occurrence RE was44.8%.Application of all the clinical and physical factors to Logistic model indicated that V50was the single statistically significant factor in the occurrence of RE(OR=1.047,95%CI:1.021-1.074,P<0.001).Conclusion Kangfuxin solution has the effect of delaying and inhibiting RE.The V50was single and the most valuable risk predictor of RE in lung neoplasms received radiation.
作者
郭智
王刚
王爱荣
徐黎
高宇
GUO Zhi;WANG Gang;WANG Ai-rong;XU Li;GAO Yu(Department of Oncology, Shanxi Traditional Chinese Medicine Hospital, Taiyuan 030001, China)
出处
《中国生化药物杂志》
CAS
2017年第12期57-59,共3页
Chinese Journal of Biochemical Pharmaceutics
关键词
急性食管炎
放射疗法
康复新液
肺恶性肿瘤
相关因素
radiation esophatitis
radiotherapy
kangfuxin solution
lung neoplasms
related factors
