摘要
目的分析降钙素联合手术治疗老年骨质疏松性桡骨远端不稳定性骨折疗效。方法选取三门县人民医院2015年1月～2017年6月收治的50例老年骨质疏松性桡骨远端不稳定性骨折患者为研究对象，分为对照组和实验组各25例。对照组与实验组均进行掌侧锁定加压钢板手术治疗，对照组口服钙尔奇D600，实验组在此基础上给予降钙素50IU，皮下注射，1次/天，2周后增加为100IU，隔天1次，连续治疗15d，1个月后给予200IU鲑鱼降钙素鼻喷剂，隔天1次。比较分析实验组与对照组患者的治疗前后健侧髋部骨密度、Mcbride评分及并发症等临床指标。结果治疗后，实验组健侧髋部骨密度为（2.28±0.23）高于对照组的（1.90±0.24），差异具有统计学意义（P＜0.05）。实验组与对照组患者Mcbride腕关节功能优良率分别为92.0%与76.0％，差异具有统计学意义（P＜0.05）。实验组与对照组均未发生严重并发症，并发症发生率分别为12.0%与16.0%，差异无统计学意义。结论降钙素联合手术治疗老年骨质疏松性桡骨远端不稳定性骨折疗效较为理想，可显著改善患者相关临床指标，恢复关节功能。
Objective To study and analyze the efficacy of calcitonin combined with surgery in the treatment of osteoporotic distal radius unstable fractures in the elderly.Methods In Sanmen County People’s Hospital from January2015to June201750elderly patients with unstable distal radius fractures were selected as the research object,They were divided into control group and experimental group with25cases in each group.Both volar locking compression plate surgical treatment control group and experimental group,control group was given oral Caltrate D600,calcitonin50IU experimental group on the basis of this,Subcutaneous injection,one time per day,2weeks later,increased to100IU,one times two day,15d for continuous treatment,200IU after1months,1times two day.A comparative analysis of the experimental group and the control group before and after treatment in patients with contralateral hip BMD,Mcbride score and complications clinical index.Results After treatment,the BMD of the hip in the experimental group was(2.28±0.23),significantly higher than that in the control group(1.90±0.24),with statistical difference(P<0.05).The excellent and good rate of Mcbride wrist joint function in the experimental group and the control group were92%and76%,respectively,with statistical difference(P<0.05).There were no serious complications in the experimental group and the control group.The incidence of complications was12%and16%respectively,and the difference was not statistically significant.Conclusion Calcitonin combined with surgery in the treatment of senile osteoporotic unstable distal radius fractures is ideal,can significantly improve patients clinical index,recovery of joint function.
作者
卢晓
徐台锋
LU Xiao;XU Tai-feng(Department of Orthopedics, Sanmen County People’s Hospital, Taizhou 317100, China)
出处
《中国生化药物杂志》
CAS
2017年第12期186-187,共2页
Chinese Journal of Biochemical Pharmaceutics
