摘要
目的分析阿托伐他汀联合化淤调脂汤对脑梗死合并颈动脉粥样硬化斑块患者血脂及血流变指标的影响。方法选取宝鸡市眉县人民医院2015年2月～2017年3月收治的50例脑梗死合并颈动脉粥样硬化斑块患者，分为实验组和对照组，各25例。实验组与对照组患者均进行常规治疗，对照组给予阿托伐他汀治疗，实验组在此基础上给予化淤调脂汤，服用4w。比较分析实验组与对照组患者的总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）和三酰甘油（TG）及全血黏度、血浆比黏度。结果治疗后，实验组患者的TC水平为（3.36±0.70）mmol/L，低于对照组TC水平为（3.99±1.12）mmol/L（P＜0.05）。实验组与对照组患者的TG水平分别为（1.10±0.21）mmol/L与（1.89±0.22）mmol/L，差异具有统计学意义（P＜0.05）。治疗后，实验组全血低切黏度为（5.12±2.10）mPa.s，低于对照组的（6.90±2.80）mPa.s（P＜0.05）。结论阿托伐他汀联合化淤调脂汤应用于脑梗死合并颈动脉粥样硬化斑块临床效果理想，可改善患者血脂情况及血流变指标。
Objective To study the effect of Atorvastatin combined with Huayu lipid-lowering decoction on blood lipid and hemorheology in patients with cerebral infarction complicated with carotid atherosclerotic plaque.Methods In Meixian People’s Hospital from February2015to March201750patients with cerebral infarction complicated with carotid atherosclerotic plaques were selected as the research objects.The experimental group and the control group were treated with routine treatment,the control group was given atorvastatin treatment,and the experimental group was given Huayu lipid-lowering decoction on the basis of this treatment for four weeks.The blood lipid indexes such as TC,HDL-C,LDL-C and TG,whole blood low shear viscosity,plasma specific viscosity and other clinical indexes were compared and analyzed between the experimental group and the control group.Results After treatment,the level of TC in the experimental group was(3.36±0.70)mmol/L,which was significantly lower than that of the control group,and the level of TC was(3.99±1.12)mmol/L,with statistical significance(P<0.05).The levels of TG in the experimental group and the control group were(1.10±0.21)mmol/L and(1.89±0.22)mmol/L,respectively,with statistical difference(P<0.05).After treatment,the whole blood low shear viscosity(5.12±2.10)mPa.s in the experimental group was significantly lower than that in the control group(6.90±2.80)mPa.s,and the difference was statistically significant(P<0.05).Conclusion Atorvastatin combined Huayu lipid-lowering decoction is effective in the treatment of cerebral infarction combined with carotid atherosclerosis plaque,which can significantly improve the blood lipid and hemorheology of patients.
作者
汶永科
WEN Yong-ke(Department of Internal Medicine, Meixian People’s Hospital, Baoji 722300, China)
出处
《中国生化药物杂志》
CAS
2017年第12期205-206,共2页
Chinese Journal of Biochemical Pharmaceutics
关键词
阿托伐他汀
化淤调脂汤
脑梗死
颈动脉粥样硬化
血脂
血流变指标
Atorvastatin
Huayu lipid-lowering decoction
cerebral infarction
carotid atherosclerotic plaque
blood lipids
blood rheology
