摘要
结直肠癌是我国最常见的恶性肿瘤之一,其发病率居高不下,腹腔种植转移作为常见转移方式,是治疗失败的常见原因之一。腹腔化疗将化疗药物注入腹腔,直接作用于腹腔内种植和脱落的癌细胞,维持腹腔内较高的有效药物浓度,延长作用时间,是治疗和预防结直肠癌腹腔种植转移的重要方法。腹腔化疗的方案种类繁多,用量及浓度也差别较大,尚无统一标准规范。为了规范结直肠癌术中腹腔化疗适应证及禁忌证的选择、规范腹腔灌注化疗药物的用法用量及术后监测指标等,中国医师协会结直肠肿瘤专业委员会组织国内相关领域权威专家,制定《结直肠癌术中腹腔化疗专家意见》,旨在规范结直肠癌术中腹腔化疗方法,提高我国结直肠肿瘤的整体诊治水平,延长结直肠癌患者生存时间并改善生活质量。
Colorectal cancer is one of the most common malignancies in China.The incidence of colorectal cancer is high,and intraperitoneal implantation is one of the common causes of treatment failure.Intraperitoneal chemotherapy,which directly injects the chemotherapeutic drugs into the abdominal cavity to inhibit the intraperitoneal implantation and shedding of cancer cells,improve the intraperitoneal effective drug concentration,and prolong the effect of time,is one of the important methods of treatment and prevention of colorectal cancer intraperitoneal transplantation.Because of many various programs,there is no uniform standard in the amount and concentration of drugs.Therefore,in order to regulate the colorectal cancer intraoperative chemotherapy indications and contraindications,regulate the usage of intraperitoneal injection of chemotherapy drugs and the monitoring indicators,the relevant experts from Colorectal Cancer Committee of Chinese Medical Doctor Association developed″Colorectal cancer intraoperative chemotherapy expert advice″.It aimed at regulate the method of colorectal cancer intraperitoneal chemotherapy,improve the overall prevention of colorectal peritoneal metastasis in China,extend the survival time of patients with colorectal cancer and improve the quality of life.
出处
《中华结直肠疾病电子杂志》
2017年第6期442-446,共5页
Chinese Journal of Colorectal Diseases(Electronic Edition)
基金
国家自然科学基金面上项目(No.81572930)
中国医学科学院肿瘤医院学科带头人奖励基金(No.RC2016003)
中国医学科学院医学与健康科技创新工程项目(No.2016-I2M-1-001)
国家重点研发计划精准医学研究专项(No.2016YFC0905300)
关键词
结直肠肿瘤
腹膜转移
术中腹腔化疗
专家意见
Colorectal neoplasms
Peritoneal metastasis
Intraperitoneal chemotherapy
Expert opinion
