摘要
目的探讨孕激素保守疗法治疗早期子宫内膜癌中的应用价值,并观察其对患者血清肿瘤标志物甲壳质酶蛋白40(YKL-40)、鳞状细胞癌抗原(SCCAg)、细胞角蛋白21-1片段(CYFRA21-1)及血清炎性因子超敏-C反应蛋白(hs-CRP)、肿瘤坏死因子α(TNF-α)、白细胞介素4(IL-4)水平的影响。方法选择早期子宫内膜癌患者96例,随机分为对照组(n=48)与研究组(n=48)。对照组患者给予刮宫手术治疗,研究组采用孕激素保守疗法治疗。采用酶联免疫吸附法(ELISA)测定并比较两组血清YKL-40、SCCAg、CYFRA21-1及hs-CRP、TNF-α、IL-4水平,观察两组治疗效果。结果治疗前,两组血清YKL-40、SCCAg、CYFRA21-1肿瘤标志物水平之间无显著差异(P>0.05);治疗后,研究组血清YKL-40、SCCAg、CYFRA21-1肿瘤标志物水平均显著低于对照组(P<0.05)。治疗前,两组血清hs-CRP、TNF-α、IL-4炎性因子水平之间无显著差异(P>0.05);治疗后,研究组血清hs-CRP、TNF-α、IL-4炎性因子水平均显著低于对照组(P<0.05)。研究组治疗总有效率为93.75%,显著高于对照组治疗总有效率68.75%(P<0.05)。研究组完全缓解患者复发率为6.25%,对照组完全缓解患者复发率为29.17%,两组比较差异有统计学意义(P<0.05)。结论与刮宫手术比较,早期子宫内膜癌患者实施孕激素保守疗法治疗的效果较佳,能够有效降低患者血清YKL-40、SCCAg、CYFRA21-1及hs-CRP、TNF-α、IL-4水平,降低患者的复发率,值得应用。
ObjectiveTo explore the application value of progesterone conservative therapy early in endometrial carcinoma,and observe the effect on serum tumor markers of chitinase protein40(YKL-40),squamous cell carcinoma antigen(SCCAg),cytokeratin fragment21-1(CYFRA21-1)and serum inflammatory factor high-sensitivity-C reactive protein(hs-CRP)tumor necrosis factor alpha(TNF-α),interleukin4(IL-4)level of influence.Methods96cases of patients with early endometrial cancer were randomly divided into control group(n=48)and study group(n=48).The control group were treated with curettage surgery treatment,the study group with progesterone conservative therapy.Serum YKL-40,SCCAg,CYFRA21-1,TNF-α,IL-4and HsCRP alpha were acquired with the ELISA method,to observe the therapeutic effect of two groups.ResultsBefore treatment,serum YKL-40,SCCAg and CYFRA21-1levels of tumor markers between two groups had no significant difference(P>0.05).serum YKL-40,SCCAg,CYFRA21-1of tumor markers in water in the study group after treatment were obviously lower than control group(P<0.05).Before treatment,no significant difference of serum hs-CRP,TNF-alpha,IL-4levels of inflammatory cytokines between the two groups were found(P>0.05).Serum hs-CRP,TNF-α,IL-4inflammatory factor levels in the study group after treatment were significantly lower than those in the control group(P<0.05).The total effective rate of the treatment group was93.75%,which was significantly higher than that of the control group(P<0.05).The total effective rate of the treatment group was significantly higher than that of the control group(P<0.05).The recurrence rate of the patients in the study group was6.25%,and the recurrence rate of the patients in the control group was significantly higher than that of the control group(P<0.05).The difference was statistically significant between the two groups.ConclusionCompared with curettage surgery,progesterone conservative treatment in early endometrial cancer patients is better,it can effectively reduce the serum levels of YKL-40,SCCAg,CYFRA21-1and hs-CRP,TNF-alpha,IL-4levels,reduce the recurrence rate,worthy of application.
作者
李婵玉
邓洁
徐蕾
罗剑波
邓晓杨
LI Chan-yu;DENG Jie;XU Lei(Department Obstetrics and Gynecology, The First Affiliated Hospital of Chengdu Medical College, Chengdu Sichuan 610500, China.)
出处
《临床和实验医学杂志》
2017年第23期2361-2364,共4页
Journal of Clinical and Experimental Medicine
关键词
子宫内膜癌
孕激素保守疗法
刮宫手术
肿瘤标志物
Endometrial carcinoma
Progesterone conservative treatment
Curettage
Serum index
