摘要
目的分析中药治疗ⅡA、ⅡB、Ⅲ期HIV/AIDS的临床疗效。方法收集云南各地医疗机构收治的中医药治疗HIV/AIDS病例,中药组给予扶正抗毒制剂或康爱保生制剂口服,中西药联合组加用HAART疗法,比较治疗前后(0月与6、12、24、36、48月)的临床症状体征评分、卡洛夫斯基评分、CD4计数、HIV-RNA载量、血常规、肝肾功等指标变化。结果纳入病例1373例。临床症状体征积分:2组治疗后均较治疗前显著下降或稳定。卡洛夫斯基评分:2组治疗后均较治疗前显著上升或稳定。CD4计数:(1)ⅡA期:中药组治疗后多数时点较治疗前显著下降;(2)ⅡB~Ⅲ期:2组治疗后均较治疗前显著上升或稳定。HIV-RNA载量:第2、3次检测值较第1次显著下降或稳定。安全性指标:治疗后较治疗前无不良变化。结论中药能改善临床症状体征、提高生存质量;不同病期CD4计数疗效存在差异,ⅡB~Ⅲ期可稳定或上升,但ⅡA期会下降。中药延缓HIV感染ⅡA期病程进展、中药联合HAART"减毒增效"等值得探索。
Objective To analyze the effect of Traditional Chinese Medicine(TCM)in treating with HIV/AIDS at the period ofⅠA,ⅡB andⅢ.Methods To collect the HIV/AIDS subjects who were treated with TCM in the medical institutions of Yunnanprovince.One group(TCM group)took Fuzheng Kangdu decoction or Kangaibaosheng decoction orally.The other group(TCM combined HAART group,TCM group)took the decoctions but accepted the treatment of HAART as well.To compare the index before and after treatment.Results1373subjects totally.After treatment the scores of signs and symptoms were decreased significantly or maintaining stability in two groups.Compared with pre-treatment,the Karnovsky score maintain stability or increased significantly in two groups.After treatment,CD4count in TCM group was decreased at the period ofⅠA but increased significantly or maintaining stability at theⅡB in two groups.HIV-RNA load was decreased significantly or maintaining stability.The index about security showed that there wasn’t any difference before and after treatment.Conclusion The TCM effect the signs and symptoms and improve the quality of life.It can maintain or raise the CD4count at the period ofⅡB andⅢ,and descend the count atⅠA.The TCM may delay the infection course atⅠA.It may be worth exploring the treatment combine TCM and HAART in the future.
作者
赵竞
王莉
柳陈坚
马克坚
方路
段呈玉
ZHAO Jing;WANG Li;LIU Chenjian;MA Kejian;FANG Lu;DUAN Chengyu(Yunnan Institute of Traditional Chinese Medicine and Materia Medica,Kunming 650223,China;;Faculty of Life Science and Technology,Kunming University of Science and Technology,Kunming 650504,China;Xishan Red House Hospital,Kunming 650118,China)
出处
《云南中医学院学报》
2017年第5期34-39,共6页
Journal of Yunnan University of Traditional Chinese Medicine
基金
云南省应用基础研究计划项目(2011FB137
2011FZ249)
云南省科技惠民专项(2013CA020)
国家中医药管理局云南省中医药治疗艾滋病试点项目
关键词
艾滋病
疗效
中药
康爱保生
扶正抗毒
HAART
云南
HIV/AIDS
effect
traditional Chinese medicine
Kangaibaosheng
Fuzheng Kangdu
HAART
Yunnan
