摘要
目的评价奥曲肽联合白蛋白治疗重症急性胰腺炎(severe acute pancreatitis,SAP)的临床疗效,为SAP的联合用药提供基础资料。方法将2015年2月至2016年9月收治的189名SAP患者分为奥曲肽组(奥曲肽静脉推注,每天1次,持续7 d)、白蛋白组(白蛋白静脉滴注,每天10 g,持续5 g)、奥曲肽联合白蛋白组(先静脉滴注白蛋白,而后使用奥曲肽静脉推注)。比较三组腹痛、体温、血淀粉酶恢复正常的时间及平均住院时间;比较外周血白细胞、内毒素水平、丙氨酸转氨酶、谷草转氨酶、血清白蛋白、Ig G、CD4/CD8的差异。结果三组腹痛消失时间、体温恢复时间、血淀粉酶恢复时间、平均住院时间的差异显著(P<0.05)。联合组较奥曲肽组及白蛋白组对改善外周血白细胞、ALT、AST效果显著(P<0.05)。联合组与奥曲肽组相比血清白蛋白水平差异显著(P<0.05),与白蛋白组相比Ig G、CD4/CD8水平差异显著(P<0.05)。结论奥曲肽联合白蛋白治疗SAP患者有助于促进其临床症状和体征的恢复,同时患者免疫功能和机体功能也得到显著改善。
Objective To evaluate the clinical efficacy of octreotide combined with albumin in the treatment of severe acute pancreatitis(SAP).Methods A total of189patients with SAP from February2015to September2016were divided into octreotide group(octreotide intravenous injection,one time per day for7days),albumin group(albumin infusion,10grams per day for5days),and combination group(intravenous albumin was infused first and then intravenously injected with octreotide).The time of abdominal pain,body temperature,blood amylase returned to normal and the average length of stay as well as the differences in peripheral blood leukocytes,endotoxin level,alanine aminotransferase,aspartate aminotransferase,serum albumin,IgG,CD4/CD8were compared among three groups.Results The disappearance time of abdominal pain,body temperature recovery time,blood amylase recovery time and average length of hospital stay were significantly different among the three groups(P<0.05).Compared with the octreotide group and albumin group,the combination group had significant effect on improving peripheral blood leukocytes,ALT and AST(P<0.05).Compared with the octreotide group,the serum albumin level of the combination group was significantly higher(P<0.05),and compared with the albumin group,the levels of IgG and CD4/CD8were significantly different(P<0.05).Conclusions Octreotide combined with albumin in the treatment of patients with SAP helps to promote the recovery of clinical symptoms and signs,and the immune function of patients has also been significantly improved.
作者
王苏
刘茂霞
郑紫丹
彭鹏
肖潇
WANG Su;LIU Mao-xia;ZHANG Zi-dan;PENG Peng;XIAO Xiao(Department of Gastroenterology,Chongqing First Aid Medical Center,Chongqing400014)
出处
《现代消化及介入诊疗》
2017年第5期635-638,共4页
Modern Interventional Diagnosis and Treatment in Gastroenterology
关键词
奥曲肽
白蛋白
重症急性胰腺炎
临床疗效
Octreotide
Albumin
Severe acute pancreatitis
Clinical curative effect
