摘要
[目的]观察辣椒素对乌拉坦诱导小鼠肺癌模型的影响。[方法]乌拉坦腹腔注射建立小鼠肺癌模型,通过小鼠的肿瘤体积,脏器指数等考察辣椒素对肺癌小鼠的影响。HE染色法观察肺病理变化。[结果]与模型组比较,辣椒素能使瘤体积增大,肺脏器指数升高,血液中TF、LY含量偏高,而WBC含量偏低(P<0.05)。HE染色结果显示,辣椒素组小鼠肺组织出现了明显的炎症浸润现象,细胞核密集;模型组与辣椒素组相比,细胞核密集区相对较少。[结论]辣椒素对乌拉坦诱导所形成的小鼠肺癌具有促进作用。
〔Objective〕To observe the effect of Capsaicin on Urethane induced lung cancer in mice.〔Methods〕The lung cancer in mice roles of capsaicin were evaluated by detecting tumor volume and lung organ index.HE staining was used to observe the pathological changes of lung.〔Results〕Compared with the model group,the tumor volume in capsaicin group was bigger,lung organ index increased,the content of TF and WBC were higher,while the content of LY were lower(P<0.05).HE staining showed that the lung tissue in the capsaicin group appeared infiltration of inflammation,the nucleus was dense;but there were relatively few dense nuclei in the model group.〔Conclusion〕Capsicin can promote the lung cancer in mice induced by urethane.
作者
李海云
林玉坤
张舒慧
段永建
杜钢军
Li Haiyun;Lin Yukun;Zhang Shuhui;Duan Yongjian;Du Gangjun(Intitute of Pharmacy, Pharmaceutical College of Henan University, Henan Kaifeng, 475004, China;The First Affiliated Hospital of Henan University, Henan Kaifeng,475004,China)
出处
《河南大学学报（医学版）》
CAS
2017年第4期243-247,共5页
Journal of Henan University:Medical Science
基金
国家自然科学基金项目(81472745)
关键词
辣椒素
乌拉坦
肺癌
capsaicin
urethane
lung cancer
