摘要
目的检测广西北海地区性病门诊泌尿生殖道感染首诊患者解脲支原体(UU)、沙眼衣原体(CT)、淋球菌(NG)、梅毒螺旋体(TP)、人类免疫缺陷病毒(HIV)等性传播疾病病原体的感染检出情况,并对规范化性病门诊的干预和防治效果进行探讨,为有效减少性传播疾病和对性传播疾病的有效干预治疗提供有价值的临床信息。方法收集590份(以泌尿生殖道症状为主诉)首诊性病患者泌尿生殖道标本的检测结果,包括病原学检测、血清TP抗体、HIV抗体检测;在干预治疗后分析治疗效果。结果 590例患者总阳性检出率为50.85%,其中泌尿生殖道感染UU、CT和NG(包括混合感染)阳性标本占49.66%,TP阳性占1.02%,HIV占0.17%。3种病原体UU、CT和NG单独感染的检出率分别为39.83%、4.58%和2.20%,三者比较差异有统计学意义(χ~2=406.33,P<0.01)。女性病原体总阳性率为68.67%,高于男性的44.78%,差异有统计学意义(χ~2=25.55,P<0.01)。支原体药敏结果显示交沙霉素、强力霉素是该地区支原体感染者较为敏感的首选治疗药物。UU和CT规范化治疗有效率较高,其余病原发生情况下,有效率均达100%,表明积极首诊后,都能取得理想的治疗效果。结论该地区就诊的泌尿生殖道感染首诊患者中,泌尿生殖道UU感染检出率在3种检测病原体中所占比例最高,有必要在高危人群中进行常规检查;女性在3种病原体总体传播过程中较男性更容易感染;根据药敏测试结果,建议北海地区支原体感染者应首选交沙霉素、强力霉素治疗;规范化治疗在北海地区取得了良好的效果。
Objective To understand the detection of pathogen infection of Ureaplasma urealyticum(UU),Chlamydia trachomatis(CT),Neisseria gonorrhoeae(NG),Treponema pallidum(TP),human immunodeficiency virus(HIV)and other sexually transmitted diseases(STD)in initially-diagnosed patients in STD clinic in Beihai district of Guangxi.And to discuss intervention and prevention effect of standardized STD clinic,so as to provide valuable clinical information for effective reduction of STD and effective intervention treatment for STD.Methods A total of590(main complaint was genitourinary tract symptoms)specimens from initially-diagnosed STD patients were collected,included pathogen detection,serum TP antibody and HIV antibody test.And then therapeutic effect was analyzed after intervention treatment.Results The total positive rate of the590patients was50.85%,including49.66%of UU,CT and NG(including mixed infection)positive specimens of genitourinary tract infection,1.02%of TP positive and0.17%of HIV.Among the three species of pathogens,the detection rate of UU,CT and NG was39.83%,4.58%and2.20%,respectively,difference between the three groups was statistically significant(χ2=406.33,P<0.01).The total positive rate of female pathogens was68.67%,which was higher than that(44.78%)of male,difference was statistically significant(χ2=25.55,P<0.01).Mycoplasma drug susceptibility results showed that josamycin and doxycycline were more sensitive to Mycoplasma infection patients in this district,thus they could be preferred in drug therapy.The effective rate of UU and CT standardized treatment was higher,and the cure rate of the other disease models was100%,indicating that ideal cure effectiveness could be obtained via positively initial diagnoses and treatment.Conclusion Among the initially-diagnosed patients with genitourinary tract infection in this region,the prevalence of UU infection in genitourinary tract is the highest among the3pathogens,and it is necessary to perform routine examinations in the population with high disease risks.Females are more likely to be infected than males in the overall transmission of the3pathogens.According to the drug sensitivity test results,patients infected by mycoplasma should be preferentially treated with Josamycin and Doxycycline in Beihai district.Standardized treatments showed good cure effectiveness for patients in this district.
作者
钟永军
韦海鹏
陈镇
陈国英
张娟华
苏腾良
黄慧嫦
曾华
HONG Yongjun;WEI Haipeng;HEN Zhen;CHEN Guoying;ZHANG Juanhua;SU Tengliang;HUANG Huichang;ZENG Hua(Dermatology & STD Department,Beihai People’s Hospital,Beihai 536000,China)
出处
《右江医学》
2017年第6期668-672,共5页
Chinese Youjiang Medical Journal
基金
广西壮族自治区卫生厅自筹经费科研课题(Z2014009)
