摘要
目的探讨引起服用华法林老年患者国际标准化比值(INR)异常变化的药物因素和机制,为老年患者安全有效使用华法林提供指导。方法回顾分析华中科技大学同济医学院附属同济医院2011—2015年监测发现INR异常变化的41例服用华法林老年住院患者的住院资料。结果 41例中INR异常升高37例(90.2%),INR异常下降4例(9.8%);静脉药物(80.5%)更易导致INR异常变化;前列地尔(26.8%)、抗真菌药(29.3%)、抗心律失常药(29.3%)、脂溶性维生素(9.8%)是引起INR异常变化的常见药物。结论服用华法林老年患者在住院期间易出现药源性凝血功能的异常变化,联用其他药物时应加强INR监测,安全有效抗凝。
ObjectiveTo investigate the unusual drug induced International Normalized Ratio(INR)change in elderly patients with warfarin treatment and its related mechanism.MethodsA retrospective analysis was performed in41cases of elderly patients with unusual drug induced INR change from2011to2015in Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology.ResultsINR was increased unusually in37cases(90.2%)and was decreased unusually in4cases(9.8%).Intravenous drugs(80.5%)were prone to cause unusual INR change.Prostaglandin,antifungal drugs,antiarrhythmic drugs and lipid soluble vitamins were the commonly used drugs that induced adverse reaction,accounting for26.8%,29.3%,29.3%and9.8%,respectively.ConclusionUnusual drug induced INR change is not rare in elderly patients with warfarin treatment during hospitalization.When other drugs are prescribed,INR should be measured more frequently and the dose of warfarin should be adjusted promptly.
作者
肖幸
周仑
高翔
张存泰
凃玲
XIAO Xing;ZHOU Lun;GAO Xiang;ZHANG Cuntai;TU Ling(Department of Geriatrics,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China)
出处
《医药导报》
CAS
北大核心
2018年第1期107-109,共3页
Herald of Medicine
关键词
华法林
国际标准化比值
不良反应
药物
患者
老年
Warfarin
International Normalized Ratio
Adverse drug reaction
Patient, elderly
