摘要
目的:探讨短期应用地西泮及苯巴比妥预防热性惊厥的临床分析。方法:选取登记建档的热性惊厥患儿共300例,随机分为地西泮组、苯巴比妥组及观察组,三组患儿入院后均根据检查结果给予有效抗感染,T≥38.5℃立即给予物理降温配合药物口服降温等常规治疗。地西泮组在发热一开始立即给予地西泮片1 mg/(kg·d),分3次口服,疗程3 d;苯巴比妥组则在发热一开始立即给予苯巴比妥片5 mg/(kg·d),分2次口服;观察组则不给予药物预防。发病后2周、热退、感染症状完全消除前提下,完善视频脑电图检查。结果:本次研究结果表明,在感染性疾病发热早期,短期应用地西泮或苯巴比妥口服,有助于明显降低热性惊厥(FC)发生,减少发热极期24 h内发作次数,缩短单次惊厥发作持续时间,减少易感年龄发作次数,降低神经元放电、缺氧对大脑中枢神经组织的继发性损伤,治疗效果分别与观察组比较差异均有统计学意义(P<0.05);地西泮及苯巴比妥在本研究对热性惊厥发作次数、单次惊厥发作持续时间、复发次数、2周后视频脑电图改变等相比较差异无统计学意义(P>0.05)。结论:在发热早期短期应用地西泮与苯巴比妥有助于降低惊厥发生率,减少发作次数,缩短发作时间,控制复发率,减轻脑组织受损;地西泮及苯巴比妥发作次数、惊厥持续时间、复发次数及远期脑电图改变等比较无明显差异,故在临床工作中地西泮、苯巴比妥均可选用。
Objective To investigate the clinical analysis of the short-term use of diazepam and phenobarbital to prevent febrile convulsion.Method A total of300children with febrile seizures were selected by registration files,they were randomly divided into diazepam group,phenobarbital group and observation group,3groups of patients were given according to the results of effective anti infection,T more than38.5DEG C for immediate physical cooling with conventional therapy for oral drug cooling.In a fever of diazepam group immediately give Diazepam Tablets1mg/(kg·d),3times of oral administration were given for3days;phenobarbital group in a fever immediately was given Phenobarbital Tablets5mg/(kg·d),2times a day;the observation group was not given the drug prevention.The video electroencephalogram(EEG)was perfected on the premise of2weeks after the onset of disease,the symptoms of fever and infection were completely eliminated.Results The results of this study showed that the infectious disease fever early,short-term use of diazepam or phenobarbital,helped to significantly reduce the occurrence of febrile convulsion(FC),to reduce the fever period within24hours of attack,shorten the single seizure duration,reduce the susceptible age episodes,reduce neuronal discharge and hypoxia the brain central nervous tissue injury secondary to treatment,and comparison of the observation group,the treatment effect was statistically significant(P<0.05);diazepam and phenobarbital in the study of febrile convulsion episodes,single seizure duration,recurrence times,after2weeks of video EEG changes compared with no significant statistical difference(P>0.05).Conclusion Helps to reduce the incidence of fever convulsion in early short term application of diazepam or phenobarbital,reduce attack frequency,shorten the onset time,control the recurrence rate,reduce the damage of brain tissue;diazepam and phenobarbital episodes,seizure duration,recurrence rate and long-term EEG changes has no significant difference in the clinical work of diazepam and phenobarbital can be chosen.
作者
林健辉
陈创鑫
姜尚林
LIN Jian-hui;CHEN Chuang-xin;JIANG Shang-lin(Department of paediatrics,Maternal and Child health care hospital of Shantou,Shantou 515000,China)
出处
《吉林医学》
CAS
2018年第2期321-323,共3页
Jilin Medical Journal
关键词
热性惊厥
小儿
地西泮
苯巴比妥
Febrile convulsion
Children
Diazepam
Phenobarbital
