摘要
目的探讨综合干预疗法联合单唾液酸四己糖神经节苷脂钠注射液对脑损伤综合征患儿的影响。方法选取2015年6月—2016年6月临沂市妇女儿童医院收治的脑损伤综合征患儿88例,采用随机数字表法分为对照组与观察组,每组44例。对照组患儿行综合干预疗法,观察组患儿在对照组基础上予以单唾液酸四己糖神经节苷脂钠注射液治疗(连续治疗6周)。比较两组患儿治疗前后Gesell发育诊断量表评分、粗大运动功能评定量表(GMFM)评分,治疗前及治疗1、3个月新生儿行为神经测定(NBNA)评分,并观察两组患儿随访期间脑瘫发生情况。结果治疗前两组患儿适应性行为评分、大运动行为评分、精细动作行为评分、语言行为评分、个人-社交行为评分比较,差异无统计学意义(P>0.05);治疗后观察组患儿适应性行为评分、大运动行为评分、精细动作行为评分、语言行为评分、个人-社交行为评分高于对照组(P<0.05)。治疗前两组患儿A区评分、B区评分、C区评分、D区评分、E区评分比较,差异无统计学意义(P>0.05);治疗后观察组患儿A区评分、B区评分、C区评分、D区评分、E区评分高于对照组(P<0.05)。治疗前两组患儿NBNA评分比较,差异无统计学意义(P>0.05);治疗1、3个月观察组患儿NBNA评分高于对照组(P<0.05)。随访期间观察组患儿脑瘫发生率低于对照组(P<0.05)。结论综合干预疗法联合单唾液酸四己糖神经节苷脂钠注射液可有效促进脑损伤综合征患儿智力发育,改善患儿粗大运动功能和神经功能,降低脑瘫发生风险。
Objective To investigate the impact of comprehensive intervention therapy combined with monosialotetrahexosyl ganglioside sodium injection on children with brain injury syndrome.Methods A total of88children with brain injury syndrome were selected in the Women and Children's Hospital of Linyi from June2015to June2016,and they were divided into control group observation group according to random number table,each of44cases.Children in control group received comprehensive intervention therapy,while children in observation group received monosialotetrahexosyl ganglioside sodium injection for6weeks based on that of control group.Gesell Development Diagnosis Scale score,Gross Motor Fuction Measure(GMFM)score before and after treatment,Neonatal Behavioral Neurological Assessment(NBNA)score before treatment,1month and3months after treatment were compared between the two groups,and incidence of brain paralysis was observed during the follow-up.Results No statistically significant differences of adaptive behavior score,major motor behavior score,fine motor behavior score,linguistic performance score or personal-social behavior score was found between the two groups before treatment(P>0.05),while adaptive behavior score,major motor behavior score,fine motor behavior score,linguistic performance score and personal-social behavior score in observation group were statistically significantly higher than those in control group after treatment(P<0.05).No statistically significant differences of A section score,B section score,C section score,D section score or E section score was found between the two groups before treatment(P>0.05),while A section score,B section score,C section score,D section score and E section score in observation group were statistically significantly higher than those in control group after treatment(P<0.05).No statistically significant differences of NBNA score was found between the two groups before treatment(P>0.05),while NBNA score in observation group was statistically significantly higher that that in control group1month and3months after treatment,respectively(P<0.05).Incidence of brain paralysis in observation group was statistically significantly lower than that in control group during the follow-up.Conclusion Comprehensive intervention therapy combined with monosialotetrahexosyl ganglioside sodium injection can effectively promote the intelligence development,gross motor function and neurological function,reduce the risk of brain paralysis in children with brain injury syndrome.
作者
李慧
LI Hui(Women and Children's Hospital of Linyi,Linyi 276017,China)
出处
《实用心脑肺血管病杂志》
2018年第1期110-113,共4页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
关键词
脑损伤
儿童
综合干预疗法
单唾液酸四己糖神经节苷脂钠注射液
治疗结果
Brain injuries
Child
Comprehensive intervention therapy
Monosialotetrahexosylganglioside injection
Treatment outcome
