摘要
目的探讨女性生殖道支原体与不孕症的关系,并对其抗生素耐药情况进行分析。方法实验组为239例确诊为不孕症的患者,对照组为239例已生育的健康妇女,对实验组及对照组进行生殖道支原体培养及药敏试验。结果实验组支原体感染率为54.4%(130/239),其中单纯解脲脲原体(Uu)感染94例(39.3%),单纯人型支原体(Mh)感染4例(1.7%),Uu+Mh混合感染32例(13.4%);对照组支原体感染率为23.8%(57/239),其中单纯Uu感染42例(17.6%),单纯Mh感染0例(0),Uu+Mh混合感染15例(6.3%),两组比较差异有统计学意义(P<0.05)。单纯Uu感染时,交沙霉素、克拉霉素、强力霉素、阿奇霉素、加替沙星及美满霉素敏感率较高,均达84%以上;单纯Mh感染及Uu+Mh混合感染时,美满霉素、强力霉素及交沙霉素敏感率较高,达90%以上。结论女性生殖道支原体和不孕症密切相关,是造成不孕的原因之一,育龄妇女应常规进行生殖道支原体检查。女性生殖道支原体对抗生素的耐药问题不容忽视,治疗前应进行药敏试验,无条件进行药敏试验时,临床经验用药应首选交沙霉素、强力霉素或美满霉素。
Objective To understand the relationship between female genital mycoplasma and infertility,and to analyze its antibiotic resistance.Methods Two hundred and thirty-nine cases of infertility were selected as experimental group,and239pregnant women were selected as control group.The culture of Mycoplasma genitum and drug sensitivity test were carried out in two groups.Results The infection rate of mycoplasma in the experimental group was54.4%(130/239),including94cases(39.3%)of the pure Uu infection,and4cases(1.7%)of the pure Mh infection,and32cases(13.4%)of the Uu+Mh mixed infection.The infection rate of mycoplasma in control group was23.8%(57/239),including42cases(17.6%)of the pure Uu infection,and0cases(0%)of the pure Mh infection,and15cases(6.3%)of the Uu+Mh mixed infection,there was significant difference between the two groups(P<0.05).In the case of pure Uu infection,the sensitivity rates of josamycin,doxycycline,minocycline,clarithromycin,azithromycin and gatifloxacin were more than84%;In the case of the pure Mh infection and the Uu+Mh mixed infection,the sensitivity rates of jacamycin,doxycycline and minocycline were more than90%.Conclusion Mycoplasma in female genital tract is closely related to infertility.It is one of the causes of infertility.Women of childbearing age should be routinely examined by Mycoplasma reproductive tract.The problem of female genital tract mycoplasma resistance to antibiotics can not be ignored,treatment should be carried out before the drug sensitivity test,unconditional drug sensitivity test,clinical use of drugs should be preferred josamycin,doxycycline or minocycline.
作者
潘开拓
姜朝新
何思杰
曾令恒
何锋荣
陈文科
PAN Kaituo;JIANG Chaoxin;HE Sijie;ZENG Lingheng;HE Fengrong;CHEN Wenke(Department of Clinical Laboratory,Nanhai Hospital, Southern Medical University, Foshan 528244,China)
出处
《中国医药科学》
2018年第4期83-85,共3页
China Medicine And Pharmacy
基金
广东省佛山市医学科研课题(20170215)
关键词
不孕症
解脲脲原体
人型支原体
敏感率
Infertility
Ureaplasma urealyticum
Mycoplasma human
Sensitivity
